Fhl2 four and a half LIM domains 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fhl2provided by MGI
Official Full Name: four and a half LIM domains 2provided by MGI
Primary source: MGI:MGI:1338762
See related: Ensembl:ENSMUSG00000008136 AllianceGenome:MGI:1338762
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FHL-2; SLIM3; SLIM-3
Summary: This gene encodes a member of the four-and-a-half-LIM-only protein family. The encoded protein functions as a regulator in numerous signaling pathways and cellular processes in development and cellular differentiation, including development and maintenance of the cardiovascular system and striated muscles. This gene also plays a role in bone formation and regulates and bone mineral content and bone mineral density. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Expression: Biased expression in heart adult (RPKM 645.6) and bladder adult (RPKM 36.0) See more
Orthologs: human all
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Genomic context

Location:: 1 C1.1; 1 22.33 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (43162233..43237501, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (43123071..43198343, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nesprin-2 is a novel scaffold protein for telethonin and FHL-2 in the cardiomyocyte sarcomere.
Title: Nesprin-2 is a novel scaffold protein for telethonin and FHL-2 in the cardiomyocyte sarcomere.
Proximal tubular FHL2, a novel downstream target of hypoxia inducible factor 1, is a protector against ischemic acute kidney injury.
Title: Proximal tubular FHL2, a novel downstream target of hypoxia inducible factor 1, is a protector against ischemic acute kidney injury.
Four-and-a-Half LIM-Domain Protein 2 (FHL2) Induces Neuropeptide Y (NPY) in Macrophages in Visceral Adipose Tissue and Promotes Diet-Induced Obesity.
Title: Four-and-a-Half LIM-Domain Protein 2 (FHL2) Induces Neuropeptide Y (NPY) in Macrophages in Visceral Adipose Tissue and Promotes Diet-Induced Obesity.
FHL2 deficiency impairs follicular development and fertility by attenuating EGF/EGFR/YAP signaling in ovarian granulosa cells.
Title: FHL2 deficiency impairs follicular development and fertility by attenuating EGF/EGFR/YAP signaling in ovarian granulosa cells.
CMYA5 is a novel interaction partner of FHL2 in cardiac myocytes.
Title: CMYA5 is a novel interaction partner of FHL2 in cardiac myocytes.
Four-and-a-half LIM domain protein 2 (FHL2) deficiency protects mice from diet-induced obesity and high FHL2 expression marks human obesity.
Title: Four-and-a-half LIM domain protein 2 (FHL2) deficiency protects mice from diet-induced obesity and high FHL2 expression marks human obesity.
FHL2 Is Essential for Spleen T Cell-Dependent B Cell Activation and Antibody Response.
Title: FHL2 Is Essential for Spleen T Cell-Dependent B Cell Activation and Antibody Response.
Deletion of the FHL2 gene attenuates intima-media thickening in a partially ligated carotid artery ligated mouse model.
Title: Deletion of the FHL2 gene attenuates intima-media thickening in a partially ligated carotid artery ligated mouse model.
LIM-only protein FHL2 attenuates vascular tissue factor activity, inhibits thrombus formation in mice and FHL2 genetic variation associates with human venous thrombosis.
Title: LIM-only protein FHL2 attenuates vascular tissue factor activity, inhibits thrombus formation in mice and FHL2 genetic variation associates with human venous thrombosis.
Four-And-A-Half LIM-Domain Protein 2 (FHL2) Deficiency Aggravates Cholestatic Liver Injury.
Title: Four-And-A-Half LIM-Domain Protein 2 (FHL2) Deficiency Aggravates Cholestatic Liver Injury.

Submit: New GeneRIF Correction See all GeneRIFs (59)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC86299P1 (e-PCR)
- UniSTS:273521

Fhl2 (e-PCR), detects polymorphism
- UniSTS:499091

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables bHLH transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription factor binding	ISO Inferred from Sequence Orthology more info
enables transcription factor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in atrial cardiac muscle cell development	IEP Inferred from Expression Pattern more info	PubMed
involved_in heart trabecula formation	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of calcineurin-NFAT signaling cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of calcineurin-NFAT signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in osteoblast differentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hormone	IEA Inferred from Electronic Annotation more info
involved_in response to hormone	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac muscle cell development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in M band	ISO Inferred from Sequence Orthology more info
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in Z disc	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: four and a half LIM domains protein 2

Names: skeletal muscle LIM-protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289533.2 → NP_001276462.1 four and a half LIM domains protein 2

See identical proteins and their annotated locations for NP_001276462.1

Status: VALIDATED

Source sequence(s)

AC161207

Consensus CDS

CCDS14922.1

UniProtKB/Swiss-Prot

O70433, P97448

UniProtKB/TrEMBL

Q543D7

Related

ENSMUSP00000141170.2, ENSMUST00000185893.2

Conserved Domains (2) summary

cd09433
Location:221 → 278

LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)

cl02475
Location:101 → 157

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001412598.1 → NP_001399527.1 four and a half LIM domains protein 2

Status: VALIDATED

Source sequence(s)

AC161207

UniProtKB/Swiss-Prot

O70433, P97448

UniProtKB/TrEMBL

Q543D7
NM_010212.5 → NP_034342.1 four and a half LIM domains protein 2

See identical proteins and their annotated locations for NP_034342.1

Status: VALIDATED

Source sequence(s)

AC161207

Consensus CDS

CCDS14922.1

UniProtKB/Swiss-Prot

O70433, P97448

UniProtKB/TrEMBL

Q543D7

Related

ENSMUSP00000008280.8, ENSMUST00000008280.14

Conserved Domains (2) summary

cd09433
Location:221 → 278

LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)

cl02475
Location:101 → 157

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers