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    Muc6 mucin 6, gastric [ Mus musculus (house mouse) ]

    Gene ID: 353328, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Muc6provided by MGI
    Official Full Name
    mucin 6, gastricprovided by MGI
    Primary source
    MGI:MGI:2663233
    See related
    Ensembl:ENSMUSG00000118661 AllianceGenome:MGI:2663233
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Is expressed in stomach and stomach glandular region gastric gland. Orthologous to human MUC6 (mucin 6, oligomeric mucus/gel-forming). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in duodenum adult (RPKM 354.4), small intestine adult (RPKM 153.2) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Muc6 in Genome Data Viewer
    Location:
    7 F5; 7 87.03 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141212404..141241659, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141633459..141655393, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene adaptor-related protein complex 2, alpha 2 subunit Neighboring gene predicted gene, 16982 Neighboring gene microRNA 7063 Neighboring gene mucin 2 Neighboring gene mucin 5, subtypes A and C, tracheobronchial/gastric

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Possible association of G6PC2 and MUC6 induced by low‑dose‑rate irradiation in mouse intestine with inflammatory bowel disease. Kang S, et al. Mol Med Rep, 2024 Jul. PMID 38785154, Free PMC Article
    2. High-fat Diet Alters the Glycosylation Patterns of Duodenal Mucins in a Murine Model. Mastrodonato M, et al. J Histochem Cytochem, 2020 Apr. PMID 32141795, Free PMC Article
    3. Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity. Gavanescu I, et al. Proc Natl Acad Sci U S A, 2007 Mar 13. PMID 17360567, Free PMC Article
    4. The characterization of the first anti-mouse Muc6 antibody shows an increased expression of the mucin in pancreatic tissue of Cftr-knockout mice. Gouyer V, et al. Histochem Cell Biol, 2010 May. PMID 20309575
    5. The mouse secreted gel-forming mucin gene cluster. Escande F, et al. Biochim Biophys Acta, 2004 Feb 20. PMID 14984930

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Possible association of G6PC2 and MUC6 induced by low-dose-rate irradiation in mouse intestine with inflammatory bowel disease.
      Title: Possible association of G6PC2 and MUC6 induced by low‑dose‑rate irradiation in mouse intestine with inflammatory bowel disease.
    2. High-fat Diet Alters the Glycosylation Patterns of Duodenal Mucins in a Murine Model.
      Title: High-fat Diet Alters the Glycosylation Patterns of Duodenal Mucins in a Murine Model.
    3. Cftr-/- mice showed a higher expression of Muc6 at both protein and RNA levels compared with their control Cftr+/+ littermates, suggesting that Muc6 may contribute to blocking of pancreatic acini and ducts in mouse models of cystic fibrosis.
      Title: The characterization of the first anti-mouse Muc6 antibody shows an increased expression of the mucin in pancreatic tissue of Cftr-knockout mice.
    4. transcription of the Mucin 6 gene in thymic medullary epithelial cells is indeed Aire-dependent
      Title: Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity.
    5. organization of the secreted gel-forming mucin gene cluster and the complete gene structure of its different members
      Title: The mouse secreted gel-forming mucin gene cluster.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mucin-6
    Names
    MUC-6
    gastric mucin-6
    gastric mucin-like protein
    secreted gel-forming mucin-6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330001.2 → NP_001316930.1  mucin-6 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102524, LXEJ02004842
      Consensus CDS
      CCDS90352.1
      UniProtKB/TrEMBL
      Q0VAV1, Q80Z18
      Conserved Domains (4) summary
      smart00215
      Location:360 → 404
      VWC_out; von Willebrand factor (vWF) type C domain
      pfam00094
      Location:869 → 1020
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:303 → 358
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:1058 → 1128
      C8; C8 domain

    2. NM_001368953.3 → NP_001355882.2  mucin-6 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC102524, LXEJ02004842
      UniProtKB/TrEMBL
      A0A7N9VSS4
      Related
      ENSMUSP00000159382.2, ENSMUST00000239500.1
      Conserved Domains (12) summary
      smart00041
      Location:4847 → 4926
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00215
      Location:360 → 404
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00216
      Location:387 → 550
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:1057 → 1129
      C8; This domain contains 8 conserved cysteine residues
      PHA03247
      Location:4320 → 4742
      PHA03247; large tegument protein UL36; Provisional
      COG3889
      Location:3886 → 4052
      COG3889; Predicted periplasmic protein [Function unknown]
      COG5422
      Location:1406 → 1624
      ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
      pfam05109
      Location:2791 → 3187
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00094
      Location:869 → 1020
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:303 → 358
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:232 → 298
      C8; C8 domain
      cd19941
      Location:765 → 828
      TIL; trypsin inhibitor-like cysteine rich domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      141212404..141241659 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153192.1 → XP_036009085.1  mucin-6 isoform X8

      Conserved Domains (7) summary
      smart00041
      Location:2151 → 2230
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00215
      Location:360 → 404
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00832
      Location:1058 → 1130
      C8; This domain contains 8 conserved cysteine residues
      pfam05109
      Location:1652 → 2041
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00094
      Location:869 → 1021
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:303 → 358
      TIL; Trypsin Inhibitor like cysteine rich domain
      cd19941
      Location:765 → 828
      TIL; trypsin inhibitor-like cysteine rich domain

    2. XM_036153186.1 → XP_036009079.1  mucin-6 isoform X2

      UniProtKB/TrEMBL
      A0A7N9VSS4
      Conserved Domains (13) summary
      smart00041
      Location:4233 → 4312
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00215
      Location:360 → 404
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00216
      Location:387 → 550
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:1058 → 1130
      C8; This domain contains 8 conserved cysteine residues
      PHA03247
      Location:3706 → 4128
      PHA03247; large tegument protein UL36; Provisional
      COG3889
      Location:3272 → 3438
      COG3889; Predicted periplasmic protein [Function unknown]
      COG5422
      Location:1407 → 1625
      ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
      pfam05109
      Location:2177 → 2573
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl17735
      Location:830 → 887
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:869 → 1021
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:303 → 358
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:232 → 298
      C8; C8 domain
      cd19941
      Location:765 → 828
      TIL; trypsin inhibitor-like cysteine rich domain

    3. XM_036153188.1 → XP_036009081.1  mucin-6 isoform X4

      UniProtKB/TrEMBL
      A0A7N9VSS4
      Conserved Domains (13) summary
      smart00041
      Location:4164 → 4243
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00215
      Location:360 → 404
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00216
      Location:387 → 550
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:1058 → 1130
      C8; This domain contains 8 conserved cysteine residues
      PHA03247
      Location:3637 → 4059
      PHA03247; large tegument protein UL36; Provisional
      COG3889
      Location:3203 → 3369
      COG3889; Predicted periplasmic protein [Function unknown]
      COG5422
      Location:1407 → 1625
      ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
      pfam05109
      Location:1727 → 2176
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl17735
      Location:830 → 887
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:869 → 1021
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:303 → 358
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:232 → 298
      C8; C8 domain
      cd19941
      Location:765 → 828
      TIL; trypsin inhibitor-like cysteine rich domain

    4. XM_036153187.1 → XP_036009080.1  mucin-6 isoform X3

      UniProtKB/TrEMBL
      A0A7N9VSS4
      Conserved Domains (12) summary
      smart00041
      Location:4233 → 4312
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00215
      Location:360 → 404
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00216
      Location:387 → 550
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:1058 → 1130
      C8; This domain contains 8 conserved cysteine residues
      PHA03247
      Location:3706 → 4128
      PHA03247; large tegument protein UL36; Provisional
      COG5422
      Location:1407 → 1625
      ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
      pfam05109
      Location:1727 → 2176
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl17735
      Location:830 → 887
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:869 → 1021
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:303 → 358
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:232 → 298
      C8; C8 domain
      cd19941
      Location:765 → 828
      TIL; trypsin inhibitor-like cysteine rich domain

    5. XM_036153189.1 → XP_036009082.1  mucin-6 isoform X5

      UniProtKB/TrEMBL
      A0A7N9VSS4
      Conserved Domains (12) summary
      smart00041
      Location:4164 → 4243
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00215
      Location:360 → 404
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00216
      Location:387 → 550
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:1058 → 1130
      C8; This domain contains 8 conserved cysteine residues
      PHA03247
      Location:3637 → 4059
      PHA03247; large tegument protein UL36; Provisional
      COG5422
      Location:1407 → 1625
      ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
      pfam05109
      Location:1727 → 2176
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl17735
      Location:830 → 887
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:869 → 1021
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:303 → 358
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:232 → 298
      C8; C8 domain
      cd19941
      Location:765 → 828
      TIL; trypsin inhibitor-like cysteine rich domain

    6. XM_036153185.1 → XP_036009078.1  mucin-6 isoform X1

      UniProtKB/TrEMBL
      A0A7N9VSS4
      Conserved Domains (13) summary
      smart00041
      Location:4506 → 4585
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00215
      Location:360 → 404
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00216
      Location:387 → 550
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:1058 → 1130
      C8; This domain contains 8 conserved cysteine residues
      PHA03247
      Location:3979 → 4401
      PHA03247; large tegument protein UL36; Provisional
      COG3889
      Location:3545 → 3711
      COG3889; Predicted periplasmic protein [Function unknown]
      COG5422
      Location:1407 → 1625
      ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
      pfam05109
      Location:1727 → 2176
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl17735
      Location:830 → 887
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:869 → 1021
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:303 → 358
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:232 → 298
      C8; C8 domain
      cd19941
      Location:765 → 828
      TIL; trypsin inhibitor-like cysteine rich domain

    7. XM_036153191.1 → XP_036009084.1  mucin-6 isoform X7

      UniProtKB/Swiss-Prot
      Q80T03, Q80Z22
      Conserved Domains (7) summary
      smart00041
      Location:2220 → 2299
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00215
      Location:360 → 404
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00832
      Location:1058 → 1130
      C8; This domain contains 8 conserved cysteine residues
      pfam05109
      Location:1464 → 1901
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00094
      Location:869 → 1021
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:303 → 358
      TIL; Trypsin Inhibitor like cysteine rich domain
      cd19941
      Location:765 → 828
      TIL; trypsin inhibitor-like cysteine rich domain

    8. XM_036153190.1 → XP_036009083.1  mucin-6 isoform X6

      Conserved Domains (3) summary
      smart00041
      Location:3327 → 3406
      CT; C-terminal cystine knot-like domain (CTCK)
      PHA03247
      Location:2789 → 3222
      PHA03247; large tegument protein UL36; Provisional
      TIGR00927
      Location:1162 → 1511
      2A1904; K+-dependent Na+/Ca+ exchanger

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_181729.3: Suppressed sequence

      Description
      NM_181729.3: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80T03.1 GenPept UniProtKB/Swiss-Prot:Q80T03

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