Mup1 major urinary protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mup1provided by MGI
Official Full Name: major urinary protein 1provided by MGI
Primary source: MGI:MGI:97233
See related: Ensembl:ENSMUSG00000078683 AllianceGenome:MGI:97233
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mup7; Up-1; Ltn-1; Mup-1; Mup-a; Mup10; Lvtn-1
Summary: Enables insulin receptor activity; pheromone activity; and pheromone binding activity. Involved in several processes, including regulation of gene expression; regulation of glucose metabolic process; and regulation of lipid metabolic process. Located in cytosol; extracellular space; and nucleus. Is expressed in several structures, including branchial arch; forelimb bud; hemolymphoid system; limb; and reproductive system. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward liver adult (RPKM 1970.0) See more
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Genomic context

Location:: 4 B3; 4 32.85 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (60454011..60457959, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (60498012..60501960, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mustn1 ablation in skeletal muscle results in increased glucose tolerance concomitant with upregulated GLUT expression in male mice.
Title: Mustn1 ablation in skeletal muscle results in increased glucose tolerance concomitant with upregulated GLUT expression in male mice.
Secreted MUP1 that reduced under ER stress attenuates ER stress induced insulin resistance through suppressing protein synthesis in hepatocytes.
Title: Secreted MUP1 that reduced under ER stress attenuates ER stress induced insulin resistance through suppressing protein synthesis in hepatocytes.
We find that differential transcription of the central Mup paralogs within and between individuals significantly increases the individuality of pheromone blends
Title: Selection on Coding and Regulatory Variation Maintains Individuality in Major Urinary Protein Scent Marks in Wild Mice.
findings suggest that the anti-HIR effect of AM251 via improvement of mitochondrial functions might occur in a MUP1-dependent manner
Title: Major urinary protein 1 interacts with cannabinoid receptor type 1 in fatty acid-induced hepatic insulin resistance in a mouse hepatocyte model.
These findings raise the possibility that MUP-1 deficiency might contribute to the metabolic dysregulation in obese/diabetic mice.
Title: Major urinary protein-1 increases energy expenditure and improves glucose intolerance through enhancing mitochondrial function in skeletal muscle of diabetic mice.
MUP1 is a regulator for glucose and lipid metabolism in mice
Title: Identification of MUP1 as a regulator for glucose and lipid metabolism in mice.
The data underline a direct role for Aire in tissue-restricted antigens expression and suggest that modulation of Aire has a potential to control central tolerance and autoimmunity.
Title: Modulation of Aire regulates the expression of tissue-restricted antigens.
Thermodynamic analysis of binding between major urinary protein-I and the pheromone 2-sec-butyl-4,5-dihydrothiazole.
Title: Thermodynamic analysis of binding between mouse major urinary protein-I and the pheromone 2-sec-butyl-4,5-dihydrothiazole.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (2) 1 citation

General gene information

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Markers

RH125017 (e-PCR)
- UniSTS:161839

Mup1 (e-PCR), detects polymorphism
- UniSTS:143934

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables insulin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables odorant binding	IBA Inferred from Biological aspect of Ancestor more info
enables pheromone activity	IDA Inferred from Direct Assay more info	PubMed
enables pheromone binding	IDA Inferred from Direct Assay more info	PubMed
enables small molecule binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to food	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipid	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to testosterone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in energy reserve metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heat generation	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in locomotor rhythm	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrion organization	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gluconeogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of lipid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of lipid storage	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of glucose metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of lipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in response to stilbenoid	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: major urinary protein 1

Names: MUP 1; major urinary protein 10; major urinary protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163010.1 → NP_001156482.1 major urinary protein 1 isoform b precursor

See identical proteins and their annotated locations for NP_001156482.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 2 and 3 both encode isoform b.

Source sequence(s)

CR589880

Consensus CDS

CCDS18231.1

UniProtKB/Swiss-Prot

P11589, Q99JF6

UniProtKB/TrEMBL

A2CEL1, B5TE76, B5X0G0

Related

ENSMUSP00000103123.4, ENSMUST00000107499.4

Conserved Domains (1) summary

pfam00061
Location:34 → 170

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
NM_001163011.1 → NP_001156483.1 major urinary protein 1 isoform a precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).

Source sequence(s)

CR589880

Consensus CDS

CCDS51188.1

UniProtKB/TrEMBL

A2CEL0

Related

ENSMUSP00000081596.5, ENSMUST00000084548.11

Conserved Domains (1) summary

pfam00061
Location:34 → 170

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
NM_031188.2 → NP_112465.2 major urinary protein 1 isoform b precursor

See identical proteins and their annotated locations for NP_112465.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of a coding exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 2 and 3 both encode isoform b.

Source sequence(s)

CR589880

Consensus CDS

CCDS18231.1

UniProtKB/Swiss-Prot

P11589, Q99JF6

UniProtKB/TrEMBL

A2CEL1, B5TE76, B5X0G0

Related

ENSMUSP00000100077.4, ENSMUST00000103012.10

Conserved Domains (1) summary

pfam00061
Location:34 → 170

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family