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    STE13 Ste13p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854394, updated on 9-Dec-2024

    Summary

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    Official Symbol
    STE13
    Official Full Name
    Ste13p
    Primary source
    SGD:S000005745
    Locus tag
    YOR219C
    See related
    AllianceGenome:SGD:S000005745; FungiDB:YOR219C; VEuPathDB:YOR219C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YCI1
    Summary
    Enables aminopeptidase activity. Involved in peptide pheromone maturation. Located in trans-Golgi network. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; asthma; autosomal dominant intellectual developmental disorder 33; and spinal muscular atrophy. Orthologous to several human genes including DPP6 (dipeptidyl peptidase like 6) and FAP (fibroblast activation protein alpha). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See STE13 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (752214..755009, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Rud3p Neighboring gene replication factor C subunit 1 Neighboring gene Rcn2p Neighboring gene [acyl-carrier-protein] S-malonyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast peptide pheromones, a-factor and alpha-factor, activate a common response mechanism in their target cells. Bender A, et al. Cell, 1986 Dec 26. PMID 3022943
    2. Isolation and DNA sequence of the STE13 gene encoding dipeptidyl aminopeptidase. Anna-Arriola SS, et al. Yeast, 1994 Jun. PMID 7975897
    3. Ultracytochemical evidence of Golgi functions in microvesicles at all phases of cell cycle in Saccharomyces cerevisiae. Vorísek J. Micron, 1995. PMID 7767635
    4. Membrane protein sorting in the yeast secretory pathway: evidence that the vacuole may be the default compartment. Roberts CJ, et al. J Cell Biol, 1992 Oct. PMID 1527174, Free PMC Article
    5. Cell-free reconstitution of transport from the trans-golgi network to the late endosome/prevacuolar compartment. Blanchette JM, et al. J Biol Chem, 2004 Nov 19. PMID 15364946

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. S13 phosphorylation is required for trans-Golgi network-to-prevacuolar compartment trafficking of A-alkaline phosphatase
      Title: Golgi-to-late endosome trafficking of the yeast pheromone processing enzyme Ste13p is regulated by a phosphorylation site in its cytosolic domain.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aminopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dipeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptide pheromone maturation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptide pheromone maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to pheromone IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ste13p
    NP_014862.3
    • Dipeptidyl aminopeptidase; Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      752214..755009 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183638.3 → NP_014862.3  TPA: Ste13p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014862.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2S4, P33894, Q9URF1
      UniProtKB/TrEMBL
      B3LJP2, B5VSA1, C7GWG4, C8ZGX3, N1NWT2
      Conserved Domains (2) summary
      COG1506
      Location:359 → 922
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00930
      Location:247 → 623
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33894.1

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