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    Dcdc2a doublecortin domain containing 2a [ Mus musculus (house mouse) ]

    Gene ID: 195208, updated on 4-Jan-2025

    Summary

    Official Symbol
    Dcdc2aprovided by MGI
    Official Full Name
    doublecortin domain containing 2aprovided by MGI
    Primary source
    MGI:MGI:2652818
    See related
    Ensembl:ENSMUSG00000035910 AllianceGenome:MGI:2652818
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RU2; Dcdc2; AW492955
    Summary
    This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Dcdc2a in Genome Data Viewer
    Location:
    13 A3.1; 13 10.89 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (25239126..25394689)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (25055273..25210706)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene glycosylphosphatidylinositol specific phospholipase D1 Neighboring gene microRNA 12184 Neighboring gene MRS2 magnesium transporter Neighboring gene predicted gene, 52042 Neighboring gene STARR-positive B cell enhancer mm9_chr13:25142251-25142552 Neighboring gene STARR-seq mESC enhancer starr_33992 Neighboring gene STARR-seq mESC enhancer starr_33993 Neighboring gene STARR-seq mESC enhancer starr_33994 Neighboring gene neurensin 1 Neighboring gene predicted gene, 34122

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    General gene information

    Clone Names

    • MGC54817

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables kinesin binding  
    enables molecular_function  
    Process Evidence Code Pubs
    involved_in cilium assembly  
    involved_in cilium assembly  
    involved_in cilium assembly  
    involved_in dendrite morphogenesis  
    acts_upstream_of_or_within dendrite morphogenesis PubMed 
    involved_in intracellular signal transduction  
    involved_in neuron migration  
    acts_upstream_of_or_within neuron migration PubMed 
    involved_in neuron migration  
    involved_in neuron migration  
    acts_upstream_of_or_within neuronal action potential PubMed 
    involved_in regulation of Wnt signaling pathway  
    involved_in regulation of Wnt signaling pathway  
    involved_in regulation of cilium assembly  
    involved_in regulation of cilium assembly  
    involved_in regulation of cilium assembly  
    acts_upstream_of sensory perception of sound PubMed 
    involved_in sensory perception of sound  
    involved_in sensory perception of sound  
    acts_upstream_of_or_within synaptic transmission, glutamatergic PubMed 
    acts_upstream_of visual learning PubMed 
    acts_upstream_of_or_within visual learning PubMed 
    Component Evidence Code Pubs
    is_active_in axoneme  
    located_in axoneme  
    located_in axoneme  
    located_in centriolar satellite  
    located_in cilium  
    located_in cilium  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    is_active_in kinocilium  
    located_in kinocilium  
    located_in kinocilium  
    is_active_in microtubule  
    located_in microtubule cytoskeleton  
    is_active_in microtubule organizing center  
    located_in mitotic spindle  
    located_in synapse  

    General protein information

    Preferred Names
    doublecortin domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195617.1NP_001182546.1  doublecortin domain-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001182546.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks several 3' exons, but has a unique 3' exon, as compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, as compared to isoform 1. The isoform 2 retains two doublecortin domains.
      Source sequence(s)
      BC045136
      Consensus CDS
      CCDS56873.1
      UniProtKB/Swiss-Prot
      Q5DU00
      Related
      ENSMUSP00000047641.9, ENSMUST00000036932.15
      Conserved Domains (2) summary
      cd01617
      Location:1796
      DCX; Ubiquitin-like domain of DCX
      smart00537
      Location:134221
      DCX; Domain in the Doublecortin (DCX) gene product
    2. NM_177577.3NP_808245.2  doublecortin domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_808245.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK220370, AL589735, AW492955, BC045136
      Consensus CDS
      CCDS26386.2
      UniProtKB/Swiss-Prot
      Q5DU00, Q5SZU0, Q80Y99
      UniProtKB/TrEMBL
      R4GML1
      Related
      ENSMUSP00000063650.7, ENSMUST00000069614.7
      Conserved Domains (4) summary
      PRK08163
      Location:69138
      PRK08163; 3-hydroxybenzoate 6-monooxygenase
      TIGR00927
      Location:246466
      2A1904; K+-dependent Na+/Ca+ exchanger
      cd17152
      Location:138217
      DCX2_DCDC2; Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2)
      cl28922
      Location:1796
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      25239126..25394689
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244294.4XP_011242596.1  doublecortin domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011242596.1

      UniProtKB/Swiss-Prot
      Q5DU00, Q5SZU0, Q80Y99
      Conserved Domains (4) summary
      PRK08163
      Location:69138
      PRK08163; 3-hydroxybenzoate 6-monooxygenase
      TIGR00927
      Location:246480
      2A1904; K+-dependent Na+/Ca+ exchanger
      cd17152
      Location:138217
      DCX2_DCDC2; Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2)
      cl28922
      Location:1796
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    2. XM_006516604.4XP_006516667.1  doublecortin domain-containing protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006516667.1

      UniProtKB/Swiss-Prot
      Q5DU00, Q5SZU0, Q80Y99
      UniProtKB/TrEMBL
      R4GML1
      Conserved Domains (4) summary
      PRK08163
      Location:69138
      PRK08163; 3-hydroxybenzoate 6-monooxygenase
      TIGR00927
      Location:246466
      2A1904; K+-dependent Na+/Ca+ exchanger
      cd17152
      Location:138217
      DCX2_DCDC2; Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2)
      cl28922
      Location:1796
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    3. XM_011244291.3XP_011242593.1  doublecortin domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011242593.1

      UniProtKB/Swiss-Prot
      Q5DU00, Q5SZU0, Q80Y99
      Conserved Domains (4) summary
      PRK08163
      Location:69138
      PRK08163; 3-hydroxybenzoate 6-monooxygenase
      TIGR00927
      Location:246480
      2A1904; K+-dependent Na+/Ca+ exchanger
      cd17152
      Location:138217
      DCX2_DCDC2; Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2)
      cl28922
      Location:1796
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    4. XM_036157923.1XP_036013816.1  doublecortin domain-containing protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q5DU00, Q5SZU0, Q80Y99
      UniProtKB/TrEMBL
      R4GML1
      Conserved Domains (4) summary
      PRK08163
      Location:69138
      PRK08163; 3-hydroxybenzoate 6-monooxygenase
      TIGR00927
      Location:246466
      2A1904; K+-dependent Na+/Ca+ exchanger
      cd17152
      Location:138217
      DCX2_DCDC2; Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2)
      cl28922
      Location:1796
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    5. XM_011244292.1XP_011242594.1  doublecortin domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011242594.1

      UniProtKB/Swiss-Prot
      Q5DU00, Q5SZU0, Q80Y99
      Conserved Domains (4) summary
      PRK08163
      Location:69138
      PRK08163; 3-hydroxybenzoate 6-monooxygenase
      TIGR00927
      Location:246480
      2A1904; K+-dependent Na+/Ca+ exchanger
      cd17152
      Location:138217
      DCX2_DCDC2; Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2)
      cl28922
      Location:1796
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    6. XM_036157924.1XP_036013817.1  doublecortin domain-containing protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q5DU00, Q5SZU0, Q80Y99
      UniProtKB/TrEMBL
      R4GML1
      Conserved Domains (4) summary
      PRK08163
      Location:69138
      PRK08163; 3-hydroxybenzoate 6-monooxygenase
      TIGR00927
      Location:246466
      2A1904; K+-dependent Na+/Ca+ exchanger
      cd17152
      Location:138217
      DCX2_DCDC2; Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2)
      cl28922
      Location:1796
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    7. XM_036157925.1XP_036013818.1  doublecortin domain-containing protein 2 isoform X3

      Conserved Domains (2) summary
      TIGR00927
      Location:111343
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl28922
      Location:1796
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
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