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    CG8773 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41634, updated on 9-Dec-2024

    Summary

    Official Symbol
    CG8773provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038135
    Locus tag
    Dmel_CG8773
    See related
    AllianceGenome:FB:FBgn0038135
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8773
    Summary
    Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Involved in dsRNA transport. Predicted to be active in cytoplasm; extracellular space; and membrane. Is expressed in adult head. Orthologous to human ENPEP (glutamyl aminopeptidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See CG8773 in Genome Data Viewer
    Location:
    87E4-87E4; 3-53 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13294748..13298288)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9120470..9124010)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Osiris 22 Neighboring gene wnt inhibitor of Dorsal Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloaminopeptidase activity  
    enables metallopeptidase activity  
    enables peptide binding  
    enables zinc ion binding  
    enables zinc ion binding  
    Process Evidence Code Pubs
    involved_in peptide catabolic process  
    involved_in proteolysis  
    involved_in proteolysis  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in extracellular space  
    is_active_in membrane  

    General protein information

    Preferred Names
    uncharacterized protein
    Names
    CG8773-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13294748..13298288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142016.3 → NP_650273.2  uncharacterized protein Dmel_CG8773 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650273.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NQ5, Q9VFX0
      Conserved Domains (3) summary
      cd09601
      Location:130 → 579
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:122 → 515
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:655 → 969
      ERAP1_C; ERAP1-like C-terminal domain
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