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    Naglu N-acetyl-alpha-glucosaminidase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 46386, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nagluprovided by FlyBase
    Official Full Name
    N-acetyl-alpha-glucosaminidaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0014417
    Locus tag
    Dmel_CG13397
    See related
    AllianceGenome:FB:FBgn0014417
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    172F5T; anon-sts19; CG13397; Dmel\CG13397; dNAGLU; ESTS:172F5T
    Summary
    Predicted to enable alpha-N-acetylglucosaminidase activity. Predicted to be involved in heparan sulfate proteoglycan catabolic process. Is active in lysosomal lumen. Is expressed in adult fat body; adult head; and adult heart. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2V; mucopolysaccharidosis III; and mucopolysaccharidosis type IIIB. Orthologous to human NAGLU (N-acetyl-alpha-glucosaminidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Naglu in Genome Data Viewer
    Location:
    29C3-29C3; 2-32 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8408888..8411868, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8408888..8411868, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44991 Neighboring gene uncharacterized protein Neighboring gene fuzzy Neighboring gene embargoed Neighboring gene uncharacterized protein Neighboring gene A kinase anchor protein 200 Neighboring gene gurken

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. dNAGLU Extends Life Span and Promotes Fitness and Stress Resistance in Drosophila. Xue R, et al. Int J Mol Sci, 2022 Nov 20. PMID 36430913, Free PMC Article
    2. One-hundred and five new potential Drosophila melanogaster genes revealed through STS analysis. Louis C, et al. Gene, 1997 Aug 22. PMID 9305763
    3. Recent Advances in Drosophila Models of Charcot-Marie-Tooth Disease. Kitani-Morii F, et al. Int J Mol Sci, 2020 Oct 8. PMID 33049996, Free PMC Article
    4. Genome-Wide Association Analyses Point to Candidate Genes for Electric Shock Avoidance in Drosophila melanogaster. Appel M, et al. PLoS One, 2015. PMID 25992709, Free PMC Article
    5. Molecular pathogenesis of peripheral neuropathies: insights from Drosophila models. Bussmann J, et al. Curr Opin Genet Dev, 2017 Jun. PMID 28213160

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-N-acetylglucosaminidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in heparan sulfate proteoglycan catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosomal lumen IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in lysosomal lumen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    N-acetyl-alpha-glucosaminidase
    Names
    CG13397-PA
    CG13397-PB
    Naglu-PA
    Naglu-PB
    NP_001260251.1
    NP_652045.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8408888..8411868 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273322.2 → NP_001260251.1  N-acetyl-alpha-glucosaminidase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260251.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TJ3, Q9VLL5
      Conserved Domains (3) summary
      pfam05089
      Location:151 → 483
      NAGLU; Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain
      pfam12971
      Location:54 → 134
      NAGLU_N; Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain
      pfam12972
      Location:490 → 748
      NAGLU_C; Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain

    2. NM_143788.4 → NP_652045.1  N-acetyl-alpha-glucosaminidase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652045.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TJ3, Q9VLL5
      Related
      FBpp0079316
      Conserved Domains (3) summary
      pfam05089
      Location:151 → 483
      NAGLU; Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain
      pfam12971
      Location:54 → 134
      NAGLU_N; Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain
      pfam12972
      Location:490 → 748
      NAGLU_C; Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VLL5 Q9VLL5

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