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    Glt Glutactin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34193, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gltprovided by FlyBase
    Official Full Name
    Glutactinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001114
    Locus tag
    Dmel_CG9280
    See related
    AllianceGenome:FB:FBgn0001114
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9280; CT26441; Dmel\CG9280; glt
    Summary
    Involved in hemolymph coagulation; motor neuron axon guidance; and synaptic target inhibition. Located in basement membrane; extracellular space; and vesicle lumen. Is expressed in several structures, including adult head; adult heart; border follicle cell; embryonic/larval fat body; and larval thoracic perisympathetic organ. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Glt in Genome Data Viewer
    Location:
    29E3-29E3; 2-33 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8672698..8676804)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8672698..8676804)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Semaphorin 1a Neighboring gene long non-coding RNA:CR43855 Neighboring gene transfer RNA:Aspartic acid-GTC 1-6 Neighboring gene transfer RNA:Aspartic acid-GTC 1-7 Neighboring gene transfer RNA:Aspartic acid-GTC 1-8 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila extracellular matrix. Fessler JH, et al. Annu Rev Cell Biol, 1989. PMID 2557060
    2. The structure-function relationships in Drosophila neurotactin show that cholinesterasic domains may have adhesive properties. Darboux I, et al. EMBO J, 1996 Sep 16. PMID 8890157, Free PMC Article
    3. Glutactin, a novel Drosophila basement membrane-related glycoprotein with sequence similarity to serine esterases. Olson PF, et al. EMBO J, 1990 Apr. PMID 2108864, Free PMC Article
    4. Characterization and gene cloning of neurotactin, a Drosophila transmembrane protein related to cholinesterases. de la Escalera S, et al. EMBO J, 1990 Nov. PMID 2120047, Free PMC Article
    5. Data on Drosophila clots and hemocyte morphologies using GFP-tagged secretory proteins: Prophenoloxidase and transglutaminase. Dziedziech A, et al. Data Brief, 2019 Aug. PMID 31367663, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables carboxylic ester hydrolase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to other organism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hemolymph coagulation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic target inhibition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vesicle lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutactin
    Names
    CG9280-PA
    CG9280-PD
    Glt-PA
    Glt-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8672698..8676804
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058156.4 → NP_477504.1  glutactin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477504.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0G5, P33438, Q9VLJ3
      UniProtKB/TrEMBL
      M9NCS8
      Related
      FBpp0079331
      Conserved Domains (3) summary
      COG0657
      Location:146 → 345
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:55 → 579
      COesterase; Carboxylesterase family
      cl23720
      Location:677 → 717
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    2. NM_001259017.2 → NP_001245946.1  glutactin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245946.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0G5, P33438, Q9VLJ3
      UniProtKB/TrEMBL
      M9NCS8
      Conserved Domains (3) summary
      COG0657
      Location:146 → 345
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:55 → 579
      COesterase; Carboxylesterase family
      cl23720
      Location:677 → 717
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NCS8 M9NCS8
    P33438.2 P33438

    Gene LinkOut

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    Chemical Information
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