kuz kuzbanian [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: kuzprovided by FlyBase
Official Full Name: kuzbanianprovided by FlyBase
Primary source: FLYBASE:FBgn0259984
Locus tag: Dmel_CG7147
See related: AllianceGenome:FB:FBgn0259984
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 11410; 34Da; ADAM10; BG:DS07660.3; br38; CG7147; CT22079; Dmel\CG7147; GS11410; Kuz; KUZ; l(2)03782; l(2)34Da; l(2)br38; l(2)c00136; l(2)k01403; l34Da; soy nut
Summary: Enables metalloendopeptidase activity. Involved in several processes, including border follicle cell migration; heart development; and nervous system development. Located in perivitelline space. Is expressed in several structures, including adult brain cell body rind; border follicle cell; embryonic/larval neuromuscular junction; epithelium; and imaginal disc. Human ortholog(s) of this gene implicated in Alzheimer's disease 18 and reticulate acropigmentation of Kitamura. Orthologous to human ADAM10 (ADAM metallopeptidase domain 10). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 34C4-34C6; 2-48 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (13550139..13639411)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (13550139..13639411)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IMP regulates Notch signalling by controlling the localisation of Kuzbanian to the apical domain, where Notch cleavage occurs, revealing a novel regulatory step in the Notch pathway.
Title: IMP regulates Kuzbanian to control the timing of Notch signalling in Drosophila follicle cells.
indicates that KUZ is required to facilitate a functional Notch signal in the Notch-dependent cell for correct cell fate specification
Title: On the roles of Notch, Delta, kuzbanian, and inscuteable during the development of Drosophila embryonic neuroblast lineages.
Kuz regulates Notch signaling primarily by activating the Notch receptor and has little overall effect on signaling via disabling Delta.
Title: Kuz and TACE can activate Notch independent of ligand.
clonal analysis of kuz in Drosophila wing
Title: kuzbanian is required cell autonomously during Notch signalling in the Drosophila wing.
KUZ regulates the relay between the G protein-coupled receptors and EGF ereceptors signaling pathways
Title: The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors.
Kuzbanian acts during lateral inhibition within the cardiac primordium. Furthermore we discuss a second function of Kuzbanian in heart cell morphogenesis.
Title: The ADAM metalloprotease Kuzbanian is crucial for proper heart formation in Drosophila melanogaster.
Notch activation and KUZ expression are restricted to border cells at stage 9 of oogenesis
Title: Spatially localized Kuzbanian required for specific activation of Notch during border cell migration.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0698 (e-PCR)
- UniSTS:56256

Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 13560515-13565210 mobile_element_type = transposon:F{}kuz[F363]
Loc: 13611261-13611320 mobile_element_type = transposon:INE-1{}2292

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch receptor processing	IDA Inferred from Direct Assay more info	PubMed
involved_in Notch receptor processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in glial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymph gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane protein ectodomain proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane protein ectodomain proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in membrane protein ectodomain proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast fate determination	IDA Inferred from Direct Assay more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pericardial nephrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of Roundabout signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of axon extension	TAS Traceable Author Statement more info	PubMed
involved_in ventral cord development	HMP more info	PubMed
involved_in ventral cord development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in perivitelline space	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kuzbanian

Names: CG7147-PA; CG7147-PB; CG7147-PC; CG7147-PF; CG7147-PG; kuz-PA; kuz-PB; kuz-PC; kuz-PF; kuz-PG; kuzbaninan; lethal (2) c00136

NP_001014481.1

EC 3.4.24.-

NP_001097159.2

EC 3.4.24.-

NP_001097160.2

EC 3.4.24.-

NP_477187.1

EC 3.4.24.-

NP_723825.1

EC 3.4.24.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

13550139..13639411

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_165047.3 → NP_723825.1 kuzbanian, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723825.1

Status: REVIEWED

UniProtKB/TrEMBL

Q94902, Q9VJW9

Related

FBpp0080088

Conserved Domains (3) summary

cd04270
Location:410 → 677

ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.

pfam00200
Location:684 → 776

Disintegrin; Disintegrin

pfam13574
Location:450 → 659

Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like
NM_001014481.3 → NP_001014481.1 kuzbanian, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014481.1

Status: REVIEWED

UniProtKB/TrEMBL

Q59DZ3, Q7YU78

Conserved Domains (3) summary

cd04270
Location:410 → 677

ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.

pfam00200
Location:684 → 776

Disintegrin; Disintegrin

pfam13574
Location:450 → 659

Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like
NM_057839.5 → NP_477187.1 kuzbanian, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477187.1

Status: REVIEWED

UniProtKB/TrEMBL

Q94902, Q9VJW9

Related

FBpp0080087

Conserved Domains (3) summary

cd04270
Location:410 → 677

ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.

pfam00200
Location:684 → 776

Disintegrin; Disintegrin

pfam13574
Location:450 → 659

Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like
NM_001103690.3 → NP_001097160.2 kuzbanian, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097160.2

Status: REVIEWED

UniProtKB/TrEMBL

A8DZ02, Q94902

Conserved Domains (3) summary

cd04270
Location:410 → 677

ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.

pfam00200
Location:684 → 776

Disintegrin; Disintegrin

pfam13574
Location:450 → 659

Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like
NM_001103689.2 → NP_001097159.2 kuzbanian, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097159.2

Status: REVIEWED

UniProtKB/TrEMBL

A8DZ03, Q94902

Conserved Domains (3) summary

cd04270
Location:410 → 677

ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.

pfam00200
Location:684 → 776

Disintegrin; Disintegrin

pfam13574
Location:450 → 659

Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like