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    CG1074 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40564, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG1074provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037250
    Locus tag
    Dmel_CG1074
    See related
    AllianceGenome:FB:FBgn0037250
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.308; Dmel\CG1074
    Summary
    Predicted to enable methyltransferase activity. Predicted to be involved in methylation. Predicted to be part of tRNA (m2G10) methyltransferase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; gut section; larval muscle system; and trunk mesoderm. Orthologous to human TRMT11 (tRNA methyltransferase 11 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG1074 in Genome Data Viewer
    Location:
    82B1-82B1; 3-47.1 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4433965..4436175)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (259687..261897)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene spargel Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 3 subunit a Neighboring gene antisense RNA:CR46138 Neighboring gene antisense RNA:CR44134 Neighboring gene Lipoyl(octanoyl) transferase 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Myopathic lamin mutations cause reductive stress and activate the nrf2/keap-1 pathway. Dialynas G, et al. PLoS Genet, 2015 May. PMID 25996830, Free PMC Article
    2. Combinatorial binding leads to diverse regulatory responses: Lmd is a tissue-specific modulator of Mef2 activity. Cunha PM, et al. PLoS Genet, 2010 Jul 1. PMID 20617173, Free PMC Article
    3. Automated identification of putative methyltransferases from genomic open reading frames. Katz JE, et al. Mol Cell Proteomics, 2003 Aug. PMID 12872006
    4. A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network. Lunardi A, et al. Proc Natl Acad Sci U S A, 2010 Apr 6. PMID 20308539, Free PMC Article
    5. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599810, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 4434424-4434469 mobile_element_type = transposon:INE-1{}3806

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanine(10)-N2)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of tRNA (m2G10) methyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG1074-PA
    NP_649471.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      4433965..4436175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141214.5 → NP_649471.3  uncharacterized protein Dmel_CG1074 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649471.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960G1, Q9VN26
      Related
      FBpp0078565
      Conserved Domains (2) summary
      COG1041
      Location:6 → 377
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
      cl17173
      Location:190 → 367
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q960G1 Q960G1

    Gene LinkOut

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