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    Rpt1 Regulatory particle triple-A ATPase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35701, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Rpt1provided by FlyBase
    Official Full Name
    Regulatory particle triple-A ATPase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0028687
    Locus tag
    Dmel_CG1341
    See related
    AllianceGenome:FB:FBgn0028687
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1341; anon-WO0118547.90; CG1341; Dmel\CG1341; Dmp48B; Dm_Rpt1; dRpt1; l(2)05643; l(2)43Ed; p48B; Q7KMQ0_DROME; S7
    Summary
    Predicted to enable proteasome-activating activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in polytene chromosome. Part of proteasome regulatory particle, base subcomplex. Is expressed in adult head and organism. Orthologous to human PSMC2 (proteasome 26S subunit, ATPase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rpt1 in Genome Data Viewer
    Location:
    43E7-43E7; 2-57 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7652440..7653954, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3539945..3541459, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44444 Neighboring gene Myosin-7a binding protein Neighboring gene antisense RNA:CR45131 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila melanogaster as a model for unraveling unique molecular features of epilepsy elicited by human GABA transporter 1 variants. Kasture AS, et al. Front Neurosci, 2022. PMID 36741049, Free PMC Article
    2. Caspase-dependent inactivation of proteasome function during programmed cell death in Drosophila and man. Adrain C, et al. J Biol Chem, 2004 Aug 27. PMID 15210720
    3. Evolution of proteasomal ATPases. Wollenberg K, et al. Mol Biol Evol, 2001 Jun. PMID 11371584
    4. Molecular characterization of the Rpt1/p48B ATPase subunit of the Drosophila melanogaster 26S proteasome. Szabó A, et al. Mol Genet Genomics, 2007 Jul. PMID 17429695
    5. Identification of PSMB5 as a genetic modifier of fragile X-associated tremor/ataxia syndrome. Kong HE, et al. Proc Natl Acad Sci U S A, 2022 May 31. PMID 35617426, Free PMC Article

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proteasome-activating activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proteasome-activating activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome regulatory particle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome regulatory particle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of proteasome regulatory particle, base subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome regulatory particle, base subcomplex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome regulatory particle, base subcomplex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    regulatory particle triple-A ATPase 1
    Names
    19S complex subunit Rpt1
    AAA ATPase
    CG1341-PA
    Rpt1-PA
    lethal(2)43Ed
    NP_477473.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7652440..7653954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058125.5 → NP_477473.1  regulatory particle triple-A ATPase 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477473.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KMQ0
      Related
      FBpp0088021
      Conserved Domains (1) summary
      COG1222
      Location:27 → 430
      RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KMQ0 Q7KMQ0

    Gene LinkOut

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