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    oxt peptide O-xylosyltransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38288, updated on 27-Dec-2024

    Summary

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    Official Symbol
    oxtprovided by FlyBase
    Official Full Name
    peptide O-xylosyltransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015360
    Locus tag
    Dmel_CG32300
    See related
    AllianceGenome:FB:FBgn0015360
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-i2; CG17771; CG17772; CG32300; Dmel\CG32300; dOXT; dXylT; Oxt; OXT
    Summary
    Enables protein xylosyltransferase activity. Involved in proteoglycan metabolic process. Predicted to be located in Golgi membrane. Is expressed in adult head; organism; and spermatozoon. Human ortholog(s) of this gene implicated in Desbuquois dysplasia; pseudoxanthoma elasticum; and type 1 diabetes mellitus. Orthologous to several human genes including XYLT1 (xylosyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See oxt in Genome Data Viewer
    Location:
    62D4-62D4; 3-2 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2258839..2262664, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2258839..2262664, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Elongator complex protein 5 Neighboring gene uncharacterized protein Neighboring gene ecdysoneless Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of Drosophila melanogaster peptide O-xylosyltransferase, the key enzyme for proteoglycan chain initiation and member of the core 2/I N-acetylglucosaminyltransferase family. Wilson IB. J Biol Chem, 2002 Jun 14. PMID 11929872
    2. XT-II, the second isoform of human peptide-O-xylosyltransferase, displays enzymatic activity. Voglmeir J, et al. J Biol Chem, 2007 Mar 2. PMID 17194707, Free PMC Article
    3. The never-ending story of peptide O-xylosyltransferase. Wilson IB. Cell Mol Life Sci, 2004 Apr. PMID 15095004, Free PMC Article
    4. Comparative characterisation of recombinant invertebrate and vertebrate peptide O-Xylosyltransferases. Brunner A, et al. Glycoconj J, 2006 Nov. PMID 17006645
    5. Dual Roles of O-Glucose Glycans Redundant with Monosaccharide O-Fucose on Notch in Notch Trafficking. Matsumoto K, et al. J Biol Chem, 2016 Jun 24. PMID 27129198, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional characterization of Drosophila melanogaster peptide O-xylosyltransferase
      Title: Functional characterization of Drosophila melanogaster peptide O-xylosyltransferase, the key enzyme for proteoglycan chain initiation and member of the core 2/I N-acetylglucosaminyltransferase family.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein xylosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein xylosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein xylosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chondroitin sulfate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chondroitin sulfate proteoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chondroitin sulfate proteoglycan biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heparan sulfate proteoglycan biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heparan sulfate proteoglycan metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteoglycan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peptide O-xylosyltransferase
    Names
    CG32300-PB
    O-xylosyltransferase
    Peptide-O-xylosyl-transferase
    Peptide-o-xylosyltransferase
    drosophila peptide O-xylosyltransferase
    oxt-PB
    NP_647705.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      2258839..2262664 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139448.4 → NP_647705.1  peptide O-xylosyltransferase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647705.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24116, Q7KVA1, Q9W034, Q9W035
      Related
      FBpp0072782
      Conserved Domains (3) summary
      pfam01822
      Location:138 → 218
      WSC; WSC domain
      pfam02485
      Location:250 → 503
      Branch; Core-2/I-Branching enzyme
      pfam12529
      Location:537 → 710
      Xylo_C; Xylosyltransferase C terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KVA1.1 Q7KVA1

    Gene LinkOut

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