U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Lcp4 Larval cuticle protein 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35820, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Lcp4provided by FlyBase
    Official Full Name
    Larval cuticle protein 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0002535
    Locus tag
    Dmel_CG2044
    See related
    AllianceGenome:FB:FBgn0002535
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4; CG2044; DmelLcp4; Dmel\CG2044; IV; LCP-4; lcp4; LCP4; L[[3]]CP4
    Summary
    A structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Located in chitin-based extracellular matrix. Is expressed in integumentary system and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Lcp4 in Genome Data Viewer
    Location:
    44D1-44D1; 2-59 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8437647..8438495)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4325152..4326000)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Larval cuticle protein 2 Neighboring gene Larval cuticle protein 3 Neighboring gene Cytochrome P450 4ad1 Neighboring gene Cytochrome P450 4e2 Neighboring gene mir-986 stem loop

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Evolution of sex chromosomes: dosage compensation of the Lcp1-4 gene cluster on the evolving neo-X chromosome in Drosophila miranda. Steinemann S, et al. Insect Mol Biol, 2007 Apr. PMID 17352708
    2. Chromatin structure at the 44D larval cuticle gene locus in Drosophila: the effect of a transposable element insertion. Eissenberg JC, et al. Nucleic Acids Res, 1984 Dec 11. PMID 6096816, Free PMC Article
    3. The cuticle genes of drosophila: a developmentally regulated gene cluster. Snyder M, et al. Cell, 1981 Jul. PMID 6168386
    4. Intertissue control of the nucleolus via a myokine-dependent longevity pathway. Demontis F, et al. Cell Rep, 2014 Jun 12. PMID 24882005, Free PMC Article
    5. Evolution of the larval cuticle proteins coded by the secondary sex chromosome pair: X2 and neo-Y of Drosophila miranda: II. Comparison at the amino acid sequence level. Steinemann M, et al. J Mol Evol, 1996 Oct. PMID 8798346

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of chitin-based larval cuticle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of chitin-based larval cuticle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of chitin-based larval cuticle ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chitin-based cuticle development ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chitin-based extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chitin-based extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chitin-based extracellular matrix ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    larval cuticle protein 4
    Names
    CG2044-PA
    CG2044-PB
    Lcp4-PA
    Lcp4-PB
    cuticle p. IV
    gene IV

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8437647..8438495
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057274.4 → NP_476622.1  larval cuticle protein 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476622.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D0IQD9, P07189, Q9V4T2
      UniProtKB/TrEMBL
      A0A0B4KEM6
      Related
      FBpp0087823
      Conserved Domains (1) summary
      pfam00379
      Location:40 → 81
      Chitin_bind_4; Insect cuticle protein

    2. NM_001273875.1 → NP_001260804.1  larval cuticle protein 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260804.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D0IQD9, P07189, Q9V4T2
      UniProtKB/TrEMBL
      A0A0B4KEM6
      Conserved Domains (1) summary
      pfam00379
      Location:40 → 81
      Chitin_bind_4; Insect cuticle protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEM6 A0A0B4KEM6
    P07189.2 P07189

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools