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    ro rough [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43234, updated on 9-Dec-2024

    Summary

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    Official Symbol
    roprovided by FlyBase
    Official Full Name
    roughprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003267
    Locus tag
    Dmel_CG6348
    See related
    AllianceGenome:FB:FBgn0003267
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6348; Dmel\CG6348; DROROUGH; Ro
    Summary
    Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in R2/R5 cell fate commitment; establishment of ommatidial planar polarity; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including embryonic brain; embryonic/larval posterior spiracle; eye disc morphogenetic furrow; photoreceptor precursor cell; and rhabdomeric photoreceptor cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    97D4-97D5; 3-92 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26876771..26881171, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22702493..22706893, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Ribonuclear protein at 97D Neighboring gene male sterile (3) K81 Neighboring gene uncharacterized protein Neighboring gene Transcript 48 Neighboring gene Ets at 97D Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pattern formation in the developing eye of Drosophila melanogaster is regulated by the homoeo-box gene, rough. Saint R, et al. Nature, 1988 Jul 14. PMID 2898735
    2. The rough (ro+) gene as a dominant P-element marker in germ line transformation of Drosophila melanogaster. Lockett TJ, et al. Gene, 1992 May 15. PMID 1601302
    3. EVOLUTION. Fruit flies diversify their offspring in response to parasite infection. Singh ND, et al. Science, 2015 Aug 14. PMID 26273057
    4. Increased exposure to acute thermal stress is associated with a non-linear increase in recombination frequency and an independent linear decrease in fitness in Drosophila. Jackson S, et al. BMC Evol Biol, 2015 Aug 27. PMID 26310872, Free PMC Article
    5. Development of the Drosophila retina, a neurocrystalline lattice. Ready DF, et al. Dev Biol, 1976 Oct 15. PMID 825400

    See all (189) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in R2/R5 cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in R2/R5 cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of ommatidial planar polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rough
    Names
    CG6348-PA
    CG6348-PB
    ro-PA
    ro-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      26876771..26881171 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170294.1 → NP_733173.1  rough, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733173.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P10181, Q24487, Q4V714, Q9VBA7
      Related
      FBpp0084461, FBtr0085091
      Conserved Domains (1) summary
      pfam00046
      Location:196 → 247
      Homeobox; Homeobox domain

    2. NM_079797.3 → NP_524521.1  rough, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524521.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P10181, Q24487, Q4V714, Q9VBA7
      Related
      FBpp0084460
      Conserved Domains (1) summary
      pfam00046
      Location:196 → 247
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10181.4 P10181

    Gene LinkOut

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