Mdr65 Multi drug resistance 65 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mdr65provided by FlyBase
Official Full Name: Multi drug resistance 65provided by FlyBase
Primary source: FLYBASE:FBgn0004513
Locus tag: Dmel_CG10181
See related: AllianceGenome:FB:FBgn0004513
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10181; Dmel\CG10181; DmMdr65; mdr65; MDR65; Mdr65A; P-glycoprotein; P-gp
Summary: Enables ABC-type xenobiotic transporter activity and efflux transmembrane transporter activity. Involved in several processes, including establishment of glial blood-brain barrier; renal tubular secretion; and xenobiotic transport. Located in pleated septate junction. Part of ATP-binding activity cassette (ABC) transporter complex. Is expressed in several structures, including adult head; embryonic/larval salivary gland; glial cell; larval brain; and ventral midline of embryo. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cholestasis (multiple); drug dependence (multiple); and human immunodeficiency virus infectious disease (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1); ABCB4 (ATP binding cassette subfamily B member 4); and ABCB5 (ATP binding cassette subfamily B member 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 65A10-65A10; 3-16 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (6240500..6245746, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (6233600..6238846, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

influences tolerance to insecticide exposure
Title: Describing the role of Drosophila melanogaster ABC transporters in insecticide biology using CRISPR-Cas9 knockouts.
mdr65 was expressed in larval tissues under stress conditions.
Title: Expression of mdr49 and mdr65 multidrug resistance genes in larval tissues of Drosophila melanogaster under normal and stress conditions.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type xenobiotic transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables efflux transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in establishment of glial blood-brain barrier	IDA Inferred from Direct Assay more info	PubMed
involved_in renal tubular secretion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insecticide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of ATP-binding cassette (ABC) transporter complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in pleated septate junction	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: multi drug resistance 65

Names: CG10181-PA; MDR65; Mdr65-PA; P-glycoprotein; P-glycoprotein65-Dm; multiple drug resistance 65

NP_476831.1

EC 7.2.2.-

EC 7.6.2.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

6240500..6245746 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057483.4 → NP_476831.1 multi drug resistance 65 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476831.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q00748, Q9VRW3

UniProtKB/TrEMBL

Q8MRC4

Related

FBpp0076719

Conserved Domains (3) summary

cd03249
Location:405 → 642

ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins

PTZ00265
Location:91 → 1300

PTZ00265; multidrug resistance protein (mdr1); Provisional

pfam00664
Location:736 → 1006

ABC_membrane; ABC transporter transmembrane region