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    HLH4C Helix loop helix protein 4C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31397, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HLH4Cprovided by FlyBase
    Official Full Name
    Helix loop helix protein 4Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011277
    Locus tag
    Dmel_CG3052
    See related
    AllianceGenome:FB:FBgn0011277
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bHLH36; CG3052; Dmel\CG3052; DroNHLH; EG:84H4.2
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in several structures, including central brain primordium; embryonic pars intercerebralis; ganglia; presumptive embryonic/larval central nervous system; and ventral nerve cord primordium. Orthologous to human NHLH1 (nescient helix-loop-helix 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See HLH4C in Genome Data Viewer
    Location:
    4C10-4C11; 1-8 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4645127..4647414, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4539160..4541447, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene partner of numb Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L30 Neighboring gene torsin Neighboring gene cap binding protein 80 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two new Drosophila genes related to human hematopoietic and neurogenic transcription factors. Varterasian M, et al. Cell Growth Differ, 1993 Nov. PMID 8297794
    2. The Drosophila basic helix-loop-helix protein DIMMED directly activates PHM, a gene encoding a neuropeptide-amidating enzyme. Park D, et al. Mol Cell Biol, 2008 Jan. PMID 17967878, Free PMC Article
    3. Multiple mechanisms drive genomic adaptation to extreme O(2) levels in Drosophila melanogaster. Iranmehr A, et al. Nat Commun, 2021 Feb 12. PMID 33579965, Free PMC Article
    4. Transcription factor expression landscape in Drosophila embryonic cell lines. Drewell RA, et al. BMC Genomics, 2024 Mar 23. PMID 38521929, Free PMC Article
    5. The basic helix-loop-helix protein family: comparative genomics and phylogenetic analysis. Ledent V, et al. Genome Res, 2001 May. PMID 11337472, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    helix loop helix protein 4C
    Names
    CG3052-PA
    CG3052-PB
    HLH4C-PA
    HLH4C-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      4645127..4647414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057641.3 → NP_476989.2  helix loop helix protein 4C, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476989.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O77278, Q9W4I4
      Related
      FBpp0070659, FBtr0070691
      Conserved Domains (1) summary
      cd00083
      Location:108 → 165
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

    2. NM_001272314.1 → NP_001259243.1  helix loop helix protein 4C, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259243.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PH26, O77278
      Conserved Domains (1) summary
      cd00083
      Location:108 → 165
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PH26 M9PH26
    Q24353 Q24353
    Q9W4I4 Q9W4I4

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