COX5A Cytochrome c oxidase subunit 5A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: COX5Aprovided by FlyBase
Official Full Name: Cytochrome c oxidase subunit 5Aprovided by FlyBase
Primary source: FLYBASE:FBgn0019624
Locus tag: Dmel_CG14724
See related: AllianceGenome:FB:FBgn0019624
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG14724; cova; CoVa; COX; COX-5A; cox5A; Cox5a; COX5a; COXA; COXA_DROME; Dmel\CG14724; mito; Q94514; tend; Va
Summary: Involved in positive regulation of cell cycle. Located in mitochondrion. Is expressed in adult head; adult heart; organism; and spermatozoon. Used to study cytochrome-c oxidase deficiency disease. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 20. Orthologous to human COX5A (cytochrome c oxidase subunit 5A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 86F9-86F9; 3-51 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (11819359..11820299)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (7645081..7646021)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, cytochrome c to oxygen	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial electron transport, cytochrome c to oxygen	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
part_of respiratory chain complex IV	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex IV	IDA Inferred from Direct Assay more info	PubMed
part_of respiratory chain complex IV	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex IV	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cytochrome c oxidase subunit 5A

Names: CG14724-PA; CG14724-PB; CG14724-PC; CG14724-PD; COX5A-PA; COX5A-PB; COX5A-PC; COX5A-PD; complex IV; cytochrome c oxidase; cytochrome c oxidase Va; cytochrome c oxidase Va, mt precursor; cytochrome c oxidase polypeptide Va; cytochrome c oxidase subunit Va; cytochrome c oxidase subunit Va preprotein; cytochrome oxidase Va; cytochrome oxidase subunit Va; cytochrome-c oxidase subunit Va; subunit 5A; subunit Va; subunit Va of complex IV; tenured

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

11819359..11820299

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057869.4 → NP_477217.1 cytochrome c oxidase subunit 5A, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477217.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q53XG7, Q94514, Q9VGH4

UniProtKB/TrEMBL

A0A0B4KFT0

Related

FBpp0081947

Conserved Domains (1) summary

cd00923
Location:33 → 136

Cyt_c_Oxidase_Va; Cytochrome c oxidase subunit Va. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
NM_169436.3 → NP_731641.1 cytochrome c oxidase subunit 5A, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731641.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q53XG7, Q94514, Q9VGH4

UniProtKB/TrEMBL

A0A0B4KFT0

Related

FBpp0081948

Conserved Domains (1) summary

cd00923
Location:33 → 136

Cyt_c_Oxidase_Va; Cytochrome c oxidase subunit Va. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
NM_001316557.1 → NP_001303486.1 cytochrome c oxidase subunit 5A, isoform D [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q53XG7, Q94514, Q9VGH4

UniProtKB/TrEMBL

A0A0B4KFT0

Conserved Domains (1) summary

cd00923
Location:33 → 136

Cyt_c_Oxidase_Va; Cytochrome c oxidase subunit Va. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
NM_001275559.1 → NP_001262488.1 cytochrome c oxidase subunit 5A, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262488.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q53XG7, Q94514, Q9VGH4

UniProtKB/TrEMBL

A0A0B4KFT0

Conserved Domains (1) summary

cd00923
Location:33 → 136

Cyt_c_Oxidase_Va; Cytochrome c oxidase subunit Va. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...