C3G C3G guanyl-nucleotide exchange factor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: C3Gprovided by FlyBase
Official Full Name: C3G guanyl-nucleotide exchange factorprovided by FlyBase
Primary source: FLYBASE:FBgn0259228
Locus tag: Dmel_CG42328
See related: AllianceGenome:FB:FBgn0259228
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: c(3)G; C(3)G; CG14436; CG3126; CG42328; DC3-G; DC3G; Dmel\CG42328
Old locus tag: Dmel_CG14436; Dmel_CG3126
Summary: Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including Ras protein signal transduction; positive regulation of smoothened signaling pathway; and sarcomere organization. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; gut section; larval central nervous system; somatic trunk mesoderm; and visceral trunk mesoderm. Orthologous to human RAPGEF1 (Rap guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 6D1-6D2; 1-18 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (6780790..6803593, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (6674823..6697626, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A 213-Amino Acid In-Frame Deletion within the Coiled-Coil Region of C(3)G Impairs the Maintenance of the synaptonemal complex in Early to Mid Pachytene.
Title: X chromosome and autosomal recombination are differentially sensitive to disruptions in SC maintenance.
C3G stimulates guanine nucleotide exchange on Drosophila Rap GTPases in vitro
Title: The Rap1 guanine nucleotide exchange factor C3G is required for preservation of larval muscle integrity in Drosophila melanogaster.
the N terminus of C(3)G is critical for the formation of antiparallel pairs of C(3)G homodimers that span the central region and thus for assembly of complete TFs, while the C terminus is required to affix these homodimers to the lateral elements.
Title: The formation of the central element of the synaptonemal complex may occur by multiple mechanisms: the roles of the N- and C-terminal domains of the Drosophila C(3)G protein in mediating synapsis and recombination.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Ras protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle attachment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: C3G guanyl-nucleotide exchange factor

Names: C3G ortholog; C3G-PC; C3G-PD; C3G-PE; C3G-PF; C3G-PG; C3G-PH; C3G-PI; C3G-PJ; C3G-PK; C3G-PL; CG42328-PC; CG42328-PD; CG42328-PE; CG42328-PF; CG42328-PG; CG42328-PH; CG42328-PI; CG42328-PJ; CG42328-PK; CG42328-PL

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

6780790..6803593 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298037.1 → NP_001284966.1 C3G guanyl-nucleotide exchange factor, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284966.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JIR4

Conserved Domains (2) summary

smart00229
Location:956 → 1092

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00155
Location:1121 → 1344

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
NM_176694.3 → NP_788867.1 C3G guanyl-nucleotide exchange factor, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788867.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O77086

Related

FBpp0289069

Conserved Domains (2) summary

smart00229
Location:1119 → 1255

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00155
Location:1284 → 1507

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
NM_001272362.1 → NP_001259291.1 C3G guanyl-nucleotide exchange factor, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259291.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PJ95

Conserved Domains (2) summary

smart00229
Location:1013 → 1149

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00155
Location:1178 → 1401

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
NM_001144695.3 → NP_001138167.1 C3G guanyl-nucleotide exchange factor, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138167.1

Status: REVIEWED

UniProtKB/TrEMBL

B7Z129

Conserved Domains (2) summary

smart00229
Location:1016 → 1152

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00155
Location:1181 → 1404

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
NM_001272364.1 → NP_001259293.1 C3G guanyl-nucleotide exchange factor, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259293.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PGJ9

Conserved Domains (2) summary

smart00229
Location:1067 → 1203

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00155
Location:1232 → 1455

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
NM_001144696.3 → NP_001138168.1 C3G guanyl-nucleotide exchange factor, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138168.1

Status: REVIEWED

UniProtKB/TrEMBL

B7Z130

Conserved Domains (2) summary

smart00229
Location:1067 → 1203

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00155
Location:1232 → 1455

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
NM_001144697.2 → NP_001138169.1 C3G guanyl-nucleotide exchange factor, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138169.1

Status: REVIEWED

UniProtKB/TrEMBL

B7Z131

Conserved Domains (2) summary

smart00229
Location:833 → 969

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00155
Location:998 → 1221

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
NM_001144694.2 → NP_001138166.1 C3G guanyl-nucleotide exchange factor, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138166.1

Status: REVIEWED

UniProtKB/TrEMBL

B7Z132

Conserved Domains (2) summary

smart00229
Location:884 → 1020

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00155
Location:1049 → 1272

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
NM_001272363.1 → NP_001259292.1 C3G guanyl-nucleotide exchange factor, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259292.1

Status: REVIEWED

UniProtKB/TrEMBL

B7Z131

Conserved Domains (2) summary

smart00229
Location:833 → 969

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00155
Location:998 → 1221

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
NM_132122.5 → NP_572350.2 C3G guanyl-nucleotide exchange factor, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572350.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O77086, Q1ECB6, Q7YU30, Q86B63, Q9W3W3

Related

FBpp0289753

Conserved Domains (2) summary

smart00229
Location:1170 → 1306

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00155
Location:1335 → 1558

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...