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    CG43689 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31353, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG43689provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263772
    Locus tag
    Dmel_CG43689
    See related
    AllianceGenome:FB:FBgn0263772
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15376; CG32778; CG32790; CG43284; CG4985; Dmel\CG43689
    Old locus tag
    Dmel_CG15376; Dmel_CG32778; Dmel_CG32790; Dmel_CG43284
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 39. Orthologous to human ST18 (ST18 C2H2C-type zinc finger transcription factor); MYT1 (myelin transcription factor 1); and MYT1L (myelin transcription factor 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG43689 in Genome Data Viewer
    Location:
    4A4-4A5; 1-6 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4075743..4092237)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (3970011..3986270)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46247 Neighboring gene long non-coding RNA:CR46349 Neighboring gene Cap methyltransferase 1 Neighboring gene uncharacterized protein Neighboring gene Xeroderma pigmentosum group A-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide in vitro and in vivo RNAi screens reveal Fer3 to be an important regulator of kkv transcription in Drosophila. Yue X, et al. Insect Sci, 2022 Jun. PMID 34351065
    2. A transcriptomic taxonomy of Drosophila circadian neurons around the clock. Ma D, et al. Elife, 2021 Jan 13. PMID 33438579, Free PMC Article
    3. The transcriptional diversity of 25 Drosophila cell lines. Cherbas L, et al. Genome Res, 2011 Feb. PMID 21177962, Free PMC Article
    4. Temporal evolution of single-cell transcriptomes of Drosophila olfactory projection neurons. Xie Q, et al. Elife, 2021 Jan 11. PMID 33427646, Free PMC Article
    5. Single-cell transcriptomes of developing and adult olfactory receptor neurons in Drosophila. McLaughlin CN, et al. Elife, 2021 Feb 8. PMID 33555999, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG43689-PC
    CG43689-PD
    CG43689-PE
    CG43689-PF
    CG43689-PG
    CG43689-PH
    CG43689-PI

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      4075743..4092237
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001370021.1 → NP_001356932.1  uncharacterized protein Dmel_CG43689, isoform I [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGM4
      Conserved Domains (1) summary
      pfam01530
      Location:1108 → 1136
      zf-C2HC; Zinc finger, C2HC type

    2. NM_001297921.1 → NP_001284850.1  uncharacterized protein Dmel_CG43689, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284850.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JCH4
      Conserved Domains (1) summary
      pfam01530
      Location:1078 → 1104
      zf-C2HC; Zinc finger, C2HC type

    3. NM_001272301.2 → NP_001259230.1  uncharacterized protein Dmel_CG43689, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259230.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PJ12
      Conserved Domains (1) summary
      pfam01530
      Location:1166 → 1192
      zf-C2HC; Zinc finger, C2HC type

    4. NM_001272300.2 → NP_001259229.1  uncharacterized protein Dmel_CG43689, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259229.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGM4
      Conserved Domains (1) summary
      pfam01530
      Location:1108 → 1136
      zf-C2HC; Zinc finger, C2HC type

    5. NM_001272298.2 → NP_001259227.1  uncharacterized protein Dmel_CG43689, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259227.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGE8
      Conserved Domains (1) summary
      pfam01530
      Location:1108 → 1134
      zf-C2HC; Zinc finger, C2HC type

    6. NM_001272299.2 → NP_001259228.1  uncharacterized protein Dmel_CG43689, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259228.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PH00
      Conserved Domains (1) summary
      pfam01530
      Location:1189 → 1215
      zf-C2HC; Zinc finger, C2HC type

    7. NM_167000.4 → NP_726905.2  uncharacterized protein Dmel_CG43689, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726905.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W4N4
      Conserved Domains (1) summary
      pfam01530
      Location:1166 → 1192
      zf-C2HC; Zinc finger, C2HC type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PGE8 M9PGE8
    M9PGM4 M9PGM4
    M9PH00 M9PH00
    M9PJ12 M9PJ12
    Q9W4N4 Q9W4N4
    X2JCH4 X2JCH4

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