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    Psf3 Partner of Sld Five 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31967, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Psf3provided by FlyBase
    Official Full Name
    Partner of Sld Five 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0030196
    Locus tag
    Dmel_CG2222
    See related
    AllianceGenome:FB:FBgn0030196
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2222; Dmel\CG2222; PSF3
    Summary
    Predicted to be involved in mitotic DNA replication initiation. Part of CMG complex and GINS complex. Is expressed in organism. Orthologous to human GINS3 (GINS complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Psf3 in Genome Data Viewer
    Location:
    9B14-9B14; 1-31 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10383353..10385861, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10277386..10279894, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene flapwing Neighboring gene uncharacterized protein Neighboring gene RabX2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mechanism of DNA unwinding by the eukaryotic replicative helicase. Burnham DR, et al. Nat Commun, 2019 May 14. PMID 31089141, Free PMC Article
    2. Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins. Ilves I, et al. Mol Cell, 2010 Jan 29. PMID 20122406, Free PMC Article
    3. The structural basis for MCM2-7 helicase activation by GINS and Cdc45. Costa A, et al. Nat Struct Mol Biol, 2011 Apr. PMID 21378962, Free PMC Article
    4. DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome. Costa A, et al. Elife, 2014 Aug 12. PMID 25117490, Free PMC Article
    5. Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase. Moyer SE, et al. Proc Natl Acad Sci U S A, 2006 Jul 5. PMID 16798881, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitotic DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CMG complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of GINS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GINS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    partner of Sld five 3
    Names
    CG2222-PA
    CG2222-PB
    CG2222-PC
    Psf3-PA
    Psf3-PB
    Psf3-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      10383353..10385861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298154.1 → NP_001285083.1  partner of Sld five 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285083.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B4F5Q5, Q9W2V7
      Conserved Domains (2) summary
      cd11713
      Location:68 → 173
      GINS_A_psf3; Alpha-helical domain of GINS complex protein Psf3 (partner of Sld5 3)
      cd21693
      Location:10 → 74
      GINS_B_Psf3; beta-strand (B) domain of GINS complex protein Psf3

    2. NM_001272477.1 → NP_001259406.1  partner of Sld five 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259406.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B4F5Q5, Q9W2V7
      Conserved Domains (2) summary
      cd11713
      Location:68 → 173
      GINS_A_psf3; Alpha-helical domain of GINS complex protein Psf3 (partner of Sld5 3)
      cd21693
      Location:10 → 74
      GINS_B_Psf3; beta-strand (B) domain of GINS complex protein Psf3

    3. NM_132396.2 → NP_572624.1  partner of Sld five 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572624.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B4F5Q5, Q9W2V7
      Related
      FBpp0071399
      Conserved Domains (2) summary
      cd11713
      Location:68 → 173
      GINS_A_psf3; Alpha-helical domain of GINS complex protein Psf3 (partner of Sld5 3)
      cd21693
      Location:10 → 74
      GINS_B_Psf3; beta-strand (B) domain of GINS complex protein Psf3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W2V7 Q9W2V7

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