U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Him Holes in muscle [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32801, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Himprovided by FlyBase
    Official Full Name
    Holes in muscleprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030900
    Locus tag
    Dmel_CG15064
    See related
    AllianceGenome:FB:FBgn0030900
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15064; Dmel\CG15064; him
    Summary
    Involved in negative regulation of muscle organ development. Is expressed in several structures, including dorsal ectoderm; dorsal pharyngeal muscle primordium; embryonic primordium of adult muscle precursor; mesoderm; and visceral mesoderm derivative. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Him in Genome Data Viewer
    Location:
    17A2-17A2; 1-60 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18209427..18210741)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18103460..18104774)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene andorra Neighboring gene Frequenin 2 Neighboring gene HES-related Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45622

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The myogenic repressor gene Holes in muscles is a direct transcriptional target of Twist and Tinman in the Drosophila embryonic mesoderm. Elwell JA, et al. Dev Biol, 2015 Apr 15. PMID 25704510, Free PMC Article
    2. The Him gene inhibits the development of Drosophila flight muscles during metamorphosis. Soler C, et al. Mech Dev, 2009 Jul. PMID 19324085
    3. The Him gene reveals a balance of inputs controlling muscle differentiation in Drosophila. Liotta D, et al. Curr Biol, 2007 Aug 21. PMID 17702578, Free PMC Article
    4. Regulation and functions of the lms homeobox gene during development of embryonic lateral transverse muscles and direct flight muscles in Drosophila. Müller D, et al. PLoS One, 2010 Dec 15. PMID 21179520, Free PMC Article
    5. Three distinct mechanisms, Notch instructive, permissive, and independent, regulate the expression of two different pericardial genes to specify cardiac cell subtypes. Panta M, et al. PLoS One, 2020. PMID 33108408, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Findings provide mechanistic insight into the brake on myogenesis that occurs during mesoderm specification: twist and tin expression at early stages in turn activate the myogenic inhibitor Him; yet, once Twist or Tin levels decline at mid-embryogenesis, Him is no longer expressed in the mesoderm, and MEF2-dependent muscle differentiation can proceed.
      Title: The myogenic repressor gene Holes in muscles is a direct transcriptional target of Twist and Tinman in the Drosophila embryonic mesoderm.
    2. Him may antagonise mef2 function during normal dorso-longitudinal muscle development.
      Title: The Him gene inhibits the development of Drosophila flight muscles during metamorphosis.
    3. Him expression rapidly declines as embryonic muscle differentiates, and consistent with this, Him overexpression inhibits muscle differentiation.
      Title: The Him gene reveals a balance of inputs controlling muscle differentiation in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of muscle organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    holes in muscle
    Names
    CG15064-PA
    Him-PA
    holes in muscles
    holes-in-muscle

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18209427..18210741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_133045.4 → NP_573273.1  holes in muscle [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573273.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWX6
      Related
      FBpp0074321
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWX6 Q9VWX6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools