CG7367 uncharacterized protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CG7367provided by FlyBase
Official Full Name: uncharacterized proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0031976
Locus tag: Dmel_CG7367
See related: AllianceGenome:FB:FBgn0031976
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Dmel\CG7367; TL
Summary: Predicted to enable triacylglycerol lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 28D3-28D3; 2-29 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (8026914..8039788, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (8026914..8039788, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipase activity	IEA Inferred from Electronic Annotation more info
enables lipase activity	ISS Inferred from Sequence or Structural Similarity more info
enables triacylglycerol lipase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in lipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: uncharacterized protein

Names: CG7367-PB; CG7367-PC; CG7367-PD

NP_001162906.1

EC 3.1.1.3

NP_001245935.1

EC 3.1.1.3

NP_609175.2

EC 3.1.1.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

8026914..8039788 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001259006.2 → NP_001245935.1 uncharacterized protein Dmel_CG7367, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245935.1

Status: REVIEWED

UniProtKB/TrEMBL

Q4V4U1, Q4V6L0

Conserved Domains (1) summary

cd00707
Location:84 → 343

Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
NM_001169435.1 → NP_001162906.1 uncharacterized protein Dmel_CG7367, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162906.1

Status: REVIEWED

UniProtKB/TrEMBL

Q4V4U1, Q4V6L0

Conserved Domains (1) summary

cd00707
Location:84 → 343

Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
NM_135331.2 → NP_609175.2 uncharacterized protein Dmel_CG7367, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_609175.2

Status: REVIEWED

UniProtKB/TrEMBL

Q4V4U1, Q9VLU1

Conserved Domains (1) summary

cd00707
Location:115 → 374

Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...