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    Vps25 Vacuolar protein sorting 25 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35847, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vps25provided by FlyBase
    Official Full Name
    Vacuolar protein sorting 25provided by FlyBase
    Primary source
    FLYBASE:FBgn0022027
    Locus tag
    Dmel_CG14750
    See related
    AllianceGenome:FB:FBgn0022027
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14750; Dmel\CG14750; dVps25; ESCRT-I; ESCRT-II; l(2)44Db; l(2)k08904; vps25; VPS25
    Summary
    Predicted to enable protein homodimerization activity and structural molecule activity. Involved in several processes, including bicoid mRNA localization; imaginal disc-derived male genitalia morphogenesis; and maintenance of epithelial cell apical/basal polarity. Predicted to be part of ESCRT II complex. Is expressed in organism. Used to study cancer and carcinoma. Orthologous to human VPS25 (vacuolar protein sorting 25 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Vps25 in Genome Data Viewer
    Location:
    44D5-44D5; 2-59 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8625451..8626180)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4512956..4513685)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene regular Neighboring gene uncharacterized protein Neighboring gene Calcium-independent receptor for alpha-latrotoxin Neighboring gene beta-1,3-Galactosyltransferase II Neighboring gene Gle1 RNA export mediator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental biology: moonlighting at the pole. Rusten TE, et al. Nature, 2007 Feb 1. PMID 17268460
    2. Dihydroceramide desaturase promotes the formation of intraluminal vesicles and inhibits autophagy to increase exosome production. Wu CY, et al. iScience, 2021 Dec 17. PMID 34877496, Free PMC Article
    3. Depletion of ESCRT ameliorates APP-induced AD-like symptoms in Drosophila. Zhuang L, et al. J Cell Physiol, 2023 Jul. PMID 37183375
    4. The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking. Vaccari T, et al. Dev Cell, 2005 Nov. PMID 16256743
    5. Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila. Thompson BJ, et al. Dev Cell, 2005 Nov. PMID 16256745

    See all (107) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ESCRT-II mutant tissues have deregulated signal transduction pathways, leading to tumorigenesis.
      Title: De-regulation of JNK and JAK/STAT signaling in ESCRT-II mutant tissues cooperatively contributes to neoplastic tumorigenesis.
    2. The non-cell autonomous induction of Yorkie is due to Notch signaling from vps25 mutant cells.
      Title: Notch signaling activates Yorkie non-cell autonomously in Drosophila.
    3. The vps25 protein encodes a component of the ESCRT-II complex, which sorts membrane proteins into multivesicular bodies during endocytic trafficking to the lysosome.
      Title: Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila.
    4. The vps25 protein, a component of the ESCRT machinery that regulates endocytic sorting of signaling receptors, as an unconventional type of Drosophila tumor suppressor.
      Title: The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural molecule activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural molecule activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in bicoid mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosomal transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosome transport via multivesicular body sorting pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial structure maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived male genitalia morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of epithelial cell apical/basal polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multivesicular body sorting pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ESCRT II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESCRT II complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ESCRT II complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vacuolar protein sorting 25
    Names
    CG14750-PA
    Vps25-PA
    lethal (2) 44Db
    vesicle protein sorting 25

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8625451..8626180
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136554.3 → NP_610398.1  vacuolar protein sorting 25 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610398.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JXV9
      Related
      FBpp0087774
      Conserved Domains (1) summary
      pfam05871
      Location:9 → 143
      ESCRT-II; ESCRT-II complex subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JXV9.1 Q7JXV9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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