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    CG8272 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35875, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8272provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033337
    Locus tag
    Dmel_CG8272
    See related
    AllianceGenome:FB:FBgn0033337
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CT8327; Dmel\CG8272; FBXL9
    Summary
    Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in organism and spermatogonium. Orthologous to human FBXL9P (F-box and leucine rich repeat protein, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8272 in Genome Data Viewer
    Location:
    44F2-44F3; 2-59 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8888404..8891401, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4775909..4778906, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene sticks and stones Neighboring gene uncharacterized protein Neighboring gene Ryanodine receptor Neighboring gene antisense RNA:CR45202 Neighboring gene Dynactin 2, p50 subunit Neighboring gene Secretory 31

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila ryanodine receptors mediate general anesthesia by halothane. Gao S, et al. Anesthesiology, 2013 Mar. PMID 23254148, Free PMC Article
    2. A conserved F-box gene with unusual transcript localization. Das T, et al. Dev Genes Evol, 2002 Apr. PMID 11976951
    3. F-box proteins: the key to protein degradation. Ho MS, et al. J Biomed Sci, 2006 Mar. PMID 16463014
    4. A systematic phenotypic screen of F-box genes through a tissue-specific RNAi-based approach in Drosophila. Dui W, et al. J Genet Genomics, 2012 Aug 20. PMID 22884096
    5. Wg/Wnt1 and Erasp link ER stress to proapoptotic signaling in an autosomal dominant retinitis pigmentosa model. Park JE, et al. Exp Mol Med, 2023 Jul. PMID 37464094, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISM
    Inferred from Sequence Model
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8272-PA
    CG8272-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8888404..8891401 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136569.4 → NP_610413.1  uncharacterized protein Dmel_CG8272, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610413.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K0V7
      Related
      FBpp0087767
      Conserved Domains (4) summary
      cd09293
      Location:515 → 642
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:322 → 346
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:12 → 44
      F-box-like; F-box-like
      cl14603
      Location:231 → 274
      C2; C2 domain

    2. NM_001273883.2 → NP_001260812.1  uncharacterized protein Dmel_CG8272, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260812.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEH1
      Conserved Domains (4) summary
      cd09293
      Location:515 → 642
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:322 → 346
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:12 → 44
      F-box-like; F-box-like
      cl14603
      Location:231 → 274
      C2; C2 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEH1 A0A0B4KEH1
    Q7K0V7 Q7K0V7

    Gene LinkOut

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