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    san separation anxiety [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44724, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sanprovided by FlyBase
    Official Full Name
    separation anxietyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024188
    Locus tag
    Dmel_CG12352
    See related
    AllianceGenome:FB:FBgn0024188
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    atado; CG12352; DmAAF34715; Dmel\CG12352; dNaa50; Naa50; NAA50; San; span
    Summary
    Enables peptide alpha-N-acetyltransferase activity. Involved in N-terminal protein amino acid acetylation; mitotic cell cycle; and mitotic sister chromatid cohesion. Located in cytosol. Part of NatA complex. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval midgut primordium; hindgut anlage; and posterior endoderm. Orthologous to human NAA50 (N-alpha-acetyltransferase 50, NatE catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See san in Genome Data Viewer
    Location:
    47F5-47F5; 2-64 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11360706..11361871)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7248211..7249376)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene intersex Neighboring gene Gustatory receptor 47b Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ehrlichia chaffeensis replication sites in adult Drosophila melanogaster. Drolia R, et al. Int J Med Microbiol, 2013 Jan. PMID 23306065, Free PMC Article
    2. A glycoprotein binding retinoids and fatty acids is present in Drosophila. Duncan T, et al. Arch Biochem Biophys, 1994 Jul. PMID 8031123
    3. Developmental roles of protein N-terminal acetylation. Silva RD, et al. Proteomics, 2015 Jul. PMID 25920796
    4. Complementary transcriptomic, lipidomic, and targeted functional genetic analyses in cultured Drosophila cells highlight the role of glycerophospholipid metabolism in Flock House virus RNA replication. Castorena KM, et al. BMC Genomics, 2010 Mar 17. PMID 20236518, Free PMC Article
    5. intersex, a gene required for female sexual development in Drosophila, is expressed in both sexes and functions together with doublesex to regulate terminal differentiation. Garrett-Engele CM, et al. Development, 2002 Oct. PMID 12361959

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggest that during tissue proliferation San behaves as general regulator of sister chromatid cohesion, as it facilitates the correct interaction between cohesin subunits Scc1/Rad21/Vtd and Smc3. Also, the results suggest a working model where Naa50/San N-terminally acetylates the nascent Scc1 polypeptide, which is subsequently required for the correct establishment and maintenance of sister chromatid cohesion.
      Title: Naa50/San-dependent N-terminal acetylation of Scc1 is potentially important for sister chromatid cohesion.
    2. san is required in vivo for normal mitosis of different types of somatic cells.
      Title: Differential requirements of a mitotic acetyltransferase in somatic and germ line cells.
    3. plays vital roles in regulating sister chromatid cohesion during Drosophila mitosis
      Title: Two putative acetyltransferases, san and deco, are required for establishing sister chromatid cohesion in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables N-acetyltransferase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables N-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide alpha-N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-terminal protein amino acid acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NatA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NatA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of NatA complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein acetyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    separation anxiety
    Names
    CG12352-PA
    N(alpha)-acetyltransferase 50
    atado
    complementation group 2
    san-PA
    NP_524779.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11360706..11361871
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080040.5 → NP_524779.1  separation anxiety [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524779.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NHD5
      Related
      FBpp0087227
      Conserved Domains (2) summary
      COG0456
      Location:27 → 145
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
      pfam00583
      Location:50 → 130
      Acetyltransf_1; Acetyltransferase (GNAT) family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NHD5.1 Q9NHD5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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