pyr pyramus [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: pyrprovided by FlyBase
Official Full Name: pyramusprovided by FlyBase
Primary source: FLYBASE:FBgn0033649
Locus tag: Dmel_CG13194
See related: AllianceGenome:FB:FBgn0033649
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG13194; DFGF8-2; Dmel\CG13194; DmPyr; fgf8-like; FGF8-like2; Pyr
Summary: Enables receptor ligand activity. Involved in several processes, including gliogenesis; larval development; and mesoderm formation. Acts upstream of with a positive effect on glial cell projection elongation. Located in extracellular space. Is expressed in several structures, including adult midgut progenitor cell; epithelium; germ layer; gut section; and neurogenic region. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 48C2-48C2; 2-65 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (11712263..11726345)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (7599768..7613850)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that Pyramus (Pyr) and Thisbe (Ths) signals play an obligatory role for the survival of the migrating cells.
Title: The FGF8-related signals Pyramus and Thisbe promote pathfinding, substrate adhesion, and survival of migrating longitudinal gut muscle founder cells.
Data show that FGF signaling regulates directional movement of caudal visceral mesoderm cells and that presentation of both FGF ligands, Pyramus and Thisbe, together is most effective at attracting cells.
Title: Synchronous and symmetric migration of Drosophila caudal visceral mesoderm cells requires dual input by two FGF ligands.
Ths and Pyr proteins are secreted from S2 cells as N-terminal fragments as a result of intracellular proteolytic cleavage; the FGF-domain is contained within the secreted ligand portion, and is functions in the embryo when ectopically expressed.
Title: Analysis of Thisbe and Pyramus functional domains reveals evidence for cleavage of Drosophila FGFs.
pyr and ths single mutants display defects in gastrulation and mesoderm differentiation.
Title: Differential and overlapping functions of two closely related Drosophila FGF8-like growth factors in mesoderm development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables fibroblast growth factor receptor binding	TAS Traceable Author Statement more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables receptor ligand activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cardioblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect glial cell projection elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval visceral muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymph gland crystal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymph gland plasmatocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesodermal cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesodermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesodermal cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mesodermal cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myoblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myotube cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pericardial nephrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: pyramus

Names: CG13194-PB; pyr-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

11712263..11726345

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001103805.2 → NP_001097275.1 pyramus [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097275.1

Status: REVIEWED

UniProtKB/TrEMBL

B9ZW35

Conserved Domains (1) summary

cl00060
Location:36 → 138

FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...