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    Pgant9 Polypeptide N-Acetylgalactosaminyltransferase 9 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 246627, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pgant9provided by FlyBase
    Official Full Name
    Polypeptide N-Acetylgalactosaminyltransferase 9provided by FlyBase
    Primary source
    FLYBASE:FBgn0050463
    Locus tag
    Dmel_CG30463
    See related
    AllianceGenome:FB:FBgn0050463
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15713; CG30463; CG8456; CG8463; Dmel\CG30463; dppGalNAcT9; pgant9; PGANT9
    Summary
    Predicted to enable polypeptide N-acetylgalactosaminyltransferase activity. Involved in protein O-linked glycosylation and sexual reproduction. Located in Golgi cisterna. Is expressed in several structures, including adult brain; adult brain cell body rind; epithelium; gut section; and imaginal disc. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to several human genes including POC1B-GALNT4 (POC1B-GALNT4 readthrough) and GALNT4 (polypeptide N-acetylgalactosaminyltransferase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pgant9 in Genome Data Viewer
    Location:
    53D1-53D4; 2-80 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16673235..16732916, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12560740..12620421, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Imaginal disc growth factor 6 Neighboring gene long non-coding RNA:CR43104 Neighboring gene long non-coding RNA:CR44464

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. O-Glycosylation of a male seminal fluid protein influences sperm binding and female postmating behavior. Zhang L, et al. PNAS Nexus, 2024 Aug. PMID 39189023, Free PMC Article
    2. A molecular switch orchestrates enzyme specificity and secretory granule morphology. Ji S, et al. Nat Commun, 2018 Aug 29. PMID 30158631, Free PMC Article
    3. Differential splicing of the lectin domain of an O-glycosyltransferase modulates both peptide and glycopeptide preferences. May C, et al. J Biol Chem, 2020 Aug 28. PMID 32669364, Free PMC Article
    4. In vivo models of mucin biosynthesis and function. Syed ZA, et al. Adv Drug Deliv Rev, 2022 May. PMID 35278522, Free PMC Article
    5. Expression of the UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase family is spatially and temporally regulated during Drosophila development. Tian E, et al. Glycobiology, 2006 Feb. PMID 16251381

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Differential splicing of the lectin domain of an O-glycosyltransferase modulates both peptide and glycopeptide preferences.
      Title: Differential splicing of the lectin domain of an O-glycosyltransferase modulates both peptide and glycopeptide preferences.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sexual reproduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    polypeptide N-Acetylgalactosaminyltransferase 9
    Names
    CG30463-PA
    CG30463-PB
    CG30463-PC
    CG30463-PD
    CG30463-PE
    Pgant9-PA
    Pgant9-PB
    Pgant9-PC
    Pgant9-PD
    Pgant9-PE
    NP_001097341.1
    NP_001097342.1
    NP_001097343.1
    NP_725602.1
    NP_725603.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16673235..16732916 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166188.2 → NP_725602.1  polypeptide N-Acetylgalactosaminyltransferase 9, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725602.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1A6R7, A1A6V9, A8DYG1, A8DYG2, A8DYG3, Q0E950, Q8MRC9, Q9V7T0
      Related
      FBpp0086258
      Conserved Domains (4) summary
      cd02510
      Location:213 → 510
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      COG0463
      Location:207 → 478
      WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
      cd00161
      Location:523 → 642
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:521 → 640
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    2. NM_166189.2 → NP_725603.2  polypeptide N-Acetylgalactosaminyltransferase 9, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725603.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MRC9
      Conserved Domains (4) summary
      cd02510
      Location:213 → 510
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      COG0463
      Location:207 → 478
      WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
      cd00161
      Location:529 → 639
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:521 → 637
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    3. NM_001103872.1 → NP_001097342.1  polypeptide N-Acetylgalactosaminyltransferase 9, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097342.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1A6R7, A1A6V9, A8DYG1, A8DYG2, A8DYG3, Q0E950, Q8MRC9, Q9V7T0
      Conserved Domains (4) summary
      cd02510
      Location:213 → 510
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      COG0463
      Location:207 → 478
      WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
      cd00161
      Location:523 → 642
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:521 → 640
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    4. NM_001103871.1 → NP_001097341.1  polypeptide N-Acetylgalactosaminyltransferase 9, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097341.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MRC9
      Conserved Domains (4) summary
      cd02510
      Location:213 → 510
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      COG0463
      Location:207 → 478
      WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
      cd00161
      Location:529 → 639
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:521 → 637
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    5. NM_001103873.1 → NP_001097343.1  polypeptide N-Acetylgalactosaminyltransferase 9, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097343.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MRC9
      Conserved Domains (3) summary
      cd00161
      Location:146 → 256
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:138 → 254
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
      cl11394
      Location:1 → 127
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MRC9.2 Q8MRC9

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