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    Oxp Oxpecker [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37002, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Oxpprovided by FlyBase
    Official Full Name
    Oxpeckerprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034255
    Locus tag
    Dmel_CG18186
    See related
    AllianceGenome:FB:FBgn0034255
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18186; Dmel\CG18186; OXP
    Summary
    Predicted to enable chromatin binding activity and methylated histone binding activity. Predicted to be involved in chromosome organization and heterochromatin formation. Predicted to be located in pericentric heterochromatin. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Oxp in Genome Data Viewer
    Location:
    54D2-54D2; 2-83 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17633797..17634167, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13521302..13521672, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene rhino Neighboring gene CCHamide-1 receptor Neighboring gene eukaryotic translation initiation factor 3 subunit c

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Recurrent Gene Duplication Diversifies Genome Defense Repertoire in Drosophila. Levine MT, et al. Mol Biol Evol, 2016 Jul. PMID 26979388, Free PMC Article
    2. Structural insights into the chromodomain of Oxpecker in complex with histone H3 lysine 9 trimethylation reveal a transposon silencing mechanism by heterodimerization. Jin Z, et al. Biochem Biophys Res Commun, 2023 Apr 16. PMID 36841100
    3. Meiotic drive mechanisms: lessons from Drosophila. Courret C, et al. Proc Biol Sci, 2019 Oct 23. PMID 31640520, Free PMC Article
    4. Drosophila rhino encodes a female-specific chromo-domain protein that affects chromosome structure and egg polarity. Volpe AM, et al. Genetics, 2001 Nov. PMID 11729157, Free PMC Article
    5. Phylogenomic analysis reveals dynamic evolutionary history of the Drosophila heterochromatin protein 1 (HP1) gene family. Levine MT, et al. PLoS Genet, 2012. PMID 22737079, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural insights into the chromodomain of Oxpecker in complex with histone H3 lysine 9 trimethylation reveal a transposon silencing mechanism by heterodimerization.
      Title: Structural insights into the chromodomain of Oxpecker in complex with histone H3 lysine 9 trimethylation reveal a transposon silencing mechanism by heterodimerization.
    2. Oxpecker Is a Recent Gene Duplicate of HP1D/Rhino. We found that the Oxpecker gene was born via gene duplication from HP1D within the last 15 million years
      Title: Recurrent Gene Duplication Diversifies Genome Defense Repertoire in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in pericentric heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    oxpecker
    Names
    CG18186-PA
    Oxp-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17633797..17634167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137396.3 → NP_611240.1  oxpecker [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611240.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAW9, Q4V4E1
      Related
      FBpp0086055
      Conserved Domains (1) summary
      cd00024
      Location:21 → 72
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZAW9 A1ZAW9

    Gene LinkOut

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