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    Pepck2 Phosphoenolpyruvate carboxykinase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37130, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Pepck2provided by FlyBase
    Official Full Name
    Phosphoenolpyruvate carboxykinase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0034356
    Locus tag
    Dmel_CG10924
    See related
    AllianceGenome:FB:FBgn0034356
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10924; Dmel\CG10924; pepck; Pepck; PEPCK; pepck2
    Summary
    Predicted to enable manganese ion binding activity and phosphoenolpyruvate carboxykinase (GTP) activity. Involved in glycerol biosynthetic process. Predicted to be located in mitochondrion. Predicted to be active in cytosol. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; gut section; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to several human genes including PCK1 (phosphoenolpyruvate carboxykinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pepck2 in Genome Data Viewer
    Location:
    55D1-55D2; 2-86 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18527430..18535749)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14414935..14423254)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Glutathione S transferase E11 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46271 Neighboring gene Phosphoenolpyruvate carboxykinase 1 Neighboring gene Rad, Gem/Kir family member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Late-life shift in caloric intake affects fly metabolism and longevity. Li M, et al. Proc Natl Acad Sci U S A, 2023 Dec 12. PMID 38064506, Free PMC Article
    2. The Drosophila foraging gene mediates adult plasticity and gene-environment interactions in behaviour, metabolites, and gene expression in response to food deprivation. Kent CF, et al. PLoS Genet, 2009 Aug. PMID 19696884, Free PMC Article
    3. Reduced branched-chain aminotransferase activity alleviates metabolic vulnerability caused by dim light exposure at night in Drosophila. Kim M, et al. J Neurogenet, 2023 Mar-Dec. PMID 36415929
    4. Anise Hyssop Agastache foeniculum Increases Lifespan, Stress Resistance, and Metabolism by Affecting Free Radical Processes in Drosophila. Strilbytska OM, et al. Front Physiol, 2020. PMID 33391017, Free PMC Article
    5. Knockdown expression of Syndecan in the fat body impacts nutrient metabolism and the organismal response to environmental stresses in Drosophila melanogaster. Eveland M, et al. Biochem Biophys Res Commun, 2016 Aug 12. PMID 27289019, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoenolpyruvate carboxykinase (GTP) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoenolpyruvate carboxykinase (GTP) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoenolpyruvate carboxykinase (GTP) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to glucose stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gluconeogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycerol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycerol biosynthetic process from pyruvate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oxaloacetate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in propionate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to lipid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in trehalose biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in triglyceride biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    phosphoenolpyruvate carboxykinase 2
    Names
    CG10924-PA
    CG10924-PB
    Pepck2-PA
    Pepck2-PB
    pepck isogene
    phosphoenol-pyruvate carboxykinase
    predicted phosphoenolpyruvate carboxykinase
    NP_001097367.1
    NP_611341.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18527430..18535749
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137497.3 → NP_611341.1  phosphoenolpyruvate carboxykinase 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611341.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JXB5
      Related
      FBpp0085878
      Conserved Domains (1) summary
      pfam00821
      Location:45 → 635
      PEPCK; Phosphoenolpyruvate carboxykinase

    2. NM_001103897.2 → NP_001097367.1  phosphoenolpyruvate carboxykinase 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097367.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYI3
      Conserved Domains (1) summary
      pfam00821
      Location:1 → 560
      PEPCK; Phosphoenolpyruvate carboxykinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8DYI3 A8DYI3
    Q7JXB5 Q7JXB5

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