GlcT Glucosylceramide synthase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: GlcTprovided by FlyBase
Official Full Name: Glucosylceramide synthaseprovided by FlyBase
Primary source: FLYBASE:FBgn0067102
Locus tag: Dmel_CG6437
See related: AllianceGenome:FB:FBgn0067102
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6437; dGlcCerT; DGlcT-1; Dmel\CG6437; GlcT-1; GlcT1
Summary: Enables ceramide glucosyltransferase activity. Involved in negative regulation of apoptotic process. Located in Golgi membrane and endoplasmic reticulum membrane. Is expressed in antennal disc; eye disc; larval imaginal tissue; leg disc; and wing disc. Orthologous to human UGCG (UDP-glucose ceramide glucosyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (22075988..22079381)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (17963493..17966886)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

GlcT-1 appears to be one of the key factors that control fat metabolism
Title: Glucosylceramide synthase in the fat body controls energy metabolism in Drosophila.
might down-regulate ceramide generated in Golgi apparatus and in the perinuclear endoplasmic reticulum.
Title: Drosophila glucosylceramide synthase: a negative regulator of cell death mediated by proapoptotic factors.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ceramide glucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ceramide glucosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glucosylceramide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

Names: CG6437-PA; GlcT-1; GlcT-PA; ceramide glucosyltransferase; glucosyltransferase

NP_611636.1

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain