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    Tpc2 Thiamine pyrophosphate carrier protein 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37983, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tpc2provided by FlyBase
    Official Full Name
    Thiamine pyrophosphate carrier protein 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0035078
    Locus tag
    Dmel_CG2857
    See related
    AllianceGenome:FB:FBgn0035078
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2857; Dmel\CG2857; DmTpc2
    Summary
    Predicted to enable antiporter activity and thiamine transmembrane transporter activity. Predicted to be involved in mitochondrial thiamine pyrophosphate transmembrane transport. Human ortholog(s) of this gene implicated in inherited metabolic disorder and microcephaly. Orthologous to human SLC25A19 (solute carrier family 25 member 19). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tpc2 in Genome Data Viewer
    Location:
    60E5-60E5; 2-107 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24897902..24900734, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20785425..20788257, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43466 Neighboring gene Na,K-ATPase Interacting Neighboring gene Ance-5 Neighboring gene Na channel protein 60E Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L41 Neighboring gene painless

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transport of platinum bonded nucleotides into proteoliposomes, mediated by Drosophila melanogaster thiamine pyrophosphate carrier protein (DmTpc1). Carrisi C, et al. J Inorg Biochem, 2014 Jan. PMID 24148759
    2. The biochemical properties of the mitochondrial thiamine pyrophosphate carrier from Drosophila melanogaster. Iacopetta D, et al. FEBS J, 2010 Mar. PMID 20121944
    3. Drosophila melanogaster Mitochondrial Carriers: Similarities and Differences with the Human Carriers. Curcio R, et al. Int J Mol Sci, 2020 Aug 22. PMID 32842667, Free PMC Article
    4. Phylogenetic Analysis Guides Transporter Protein Deorphanization: A Case Study of the SLC25 Family of Mitochondrial Metabolite Transporters. Byrne KL, et al. Biomolecules, 2023 Aug 28. PMID 37759714, Free PMC Article
    5. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables thiamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiamine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial thiamine pyrophosphate transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in thiamine pyrophosphate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    thiamine pyrophosphate carrier protein 2
    Names
    CG2857-PB
    Tpc2-PB
    thiamine pyrophosphate carrier protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24897902..24900734 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259582.2 → NP_001246511.1  thiamine pyrophosphate carrier protein 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246511.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W0Y9
      Conserved Domains (2) summary
      PTZ00169
      Location:23 → 304
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:216 → 307
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W0Y9 Q9W0Y9

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