CG7394 uncharacterized protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CG7394provided by FlyBase
Official Full Name: uncharacterized proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0036173
Locus tag: Dmel_CG7394
See related: AllianceGenome:FB:FBgn0036173
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:RE52392; D.M.UKP; Dmel\CG7394; TIM14
Summary: Predicted to enable ATPase activator activity. Predicted to be involved in protein import into mitochondrial matrix. Predicted to be part of PAM complex, Tim23 associated import motor. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 5. Orthologous to several human genes including DNAJC19 (DnaJ heat shock protein family (Hsp40) member C19). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 68C13-68C13; 3-36 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (11561996..11564312)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (11555096..11557412)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase activator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in protein import into mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of PAM complex, Tim23 associated import motor	IBA Inferred from Biological aspect of Ancestor more info
part_of PAM complex, Tim23 associated import motor	ISS Inferred from Sequence or Structural Similarity more info
part_of TIM23 mitochondrial import inner membrane translocase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: uncharacterized protein

Names: CG7394-PA; CG7394-PB; CG7394-PC; CG7394-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

11561996..11564312

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274785.1 → NP_001261714.1 uncharacterized protein Dmel_CG7394, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261714.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8SYM8, Q9VTJ8

UniProtKB/TrEMBL

M9NDP2

Conserved Domains (1) summary

cl02542
Location:5 → 116

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
NM_001259788.2 → NP_001246717.1 uncharacterized protein Dmel_CG7394, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246717.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8SYM8, Q9VTJ8

UniProtKB/TrEMBL

M9NDP2

Conserved Domains (1) summary

cl02542
Location:5 → 116

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
NM_140218.4 → NP_648475.1 uncharacterized protein Dmel_CG7394, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648475.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8SYM8, Q9VTJ8

UniProtKB/TrEMBL

M9NDP2

Related

FBpp0075829

Conserved Domains (1) summary

cl02542
Location:5 → 116

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
NM_001144461.1 → NP_001137933.1 uncharacterized protein Dmel_CG7394, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137933.1

Status: REVIEWED

UniProtKB/TrEMBL

B7Z0G3

Conserved Domains (1) summary

cl02542
Location:15 → 126

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...