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    Sema5c Semaphorin 5c [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37066, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sema5cprovided by FlyBase
    Official Full Name
    Semaphorin 5cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0284221
    Locus tag
    Dmel_CG5661
    See related
    AllianceGenome:FB:FBgn0284221
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:CK02567; BG01245; CG5661; CK02567; CT17880; Dmel\CG5661; Dsema3a; sema 5c; Sema 5c; Sema-3a; Sema-5; sema-5c; sema-5C; Sema-5c; Sema-5C; Sema3A; sema5c
    Summary
    Predicted to enable chemorepellent activity and semaphorin receptor binding activity. Involved in central complex development; embryonic development via the syncytial blastoderm; and olfactory behavior. Predicted to be active in plasma membrane. Is expressed in several structures, including embryonic/larval midgut primordium; epidermis; germ layer; gut section; and head epidermis primordium. Orthologous to several human genes including SEMA5B (semaphorin 5B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Sema5c in Genome Data Viewer
    Location:
    68F2-68F2; 3-38 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12067511..12081830, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12060611..12074930, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene rolling pebbles Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene versatile

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extensive epistasis for olfactory behaviour, sleep and waking activity in Drosophila melanogaster. Swarup S, et al. Genet Res (Camb), 2012 Feb. PMID 22353245, Free PMC Article
    2. Expression patterns of two new members of the Semaphorin family in Drosophila suggest early functions during embryogenesis. Khare N, et al. Mech Dev, 2000 Mar 1. PMID 10704872
    3. Two distinct mechanisms of Plexin A function in Drosophila optic lobe lamination and morphogenesis. Bustillo ME, et al. Development, 2024 May 15. PMID 38738602,
    4. The semaphorins. Yazdani U, et al. Genome Biol, 2006. PMID 16584533, Free PMC Article
    5. Fat2 polarizes Lar and Sema5c to coordinate the motility of collectively migrating epithelial cells. Williams AM, et al. J Cell Sci, 2024 Mar 1. PMID 37593878, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fat2 polarizes Lar and Sema5c to coordinate the motility of collectively migrating epithelial cells.
      Title: Fat2 polarizes Lar and Sema5c to coordinate the motility of collectively migrating epithelial cells.
    2. Sema-5c antagonizes the activity of Lar, another transmembrane guidance cue that operates along leading-trailing cell-cell interfaces in this tissue, via a mechanism that appears to be independent of Plexin A.
      Title: Planar-Polarized Semaphorin-5c and Plexin A Promote the Collective Migration of Epithelial Cells in Drosophila.
    3. hypomorphic mutation of this developmental gene results in genomewide transcriptional consequences and alterations in brain structure accompanied by profound impairment of adult behavior.
      Title: The early developmental gene Semaphorin 5c contributes to olfactory behavior in adult Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chemorepellent activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables semaphorin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables semaphorin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in central complex development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic development via the syncytial blastoderm IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in olfactory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in semaphorin-plexin signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    semaphorin 5c
    Names
    CG5661-PA
    CG5661-PB
    Sema-3a
    Sema-5c
    Sema5c-PA
    Sema5c-PB
    Semaphorin-5c
    semaphorin
    semaphorin 5C
    semiphorin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12067511..12081830 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137449.3 → NP_611293.3  semaphorin 5c, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611293.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7YU67, Q9U631, Q9VTT0
      Related
      FBpp0075784
      Conserved Domains (3) summary
      cd11265
      Location:65 → 496
      Sema_5C; The Sema domain, a protein interacting module, of semaphorin 5C (sema5C)
      smart00209
      Location:674 → 725
      TSP1; Thrombospondin type 1 repeats
      pfam01437
      Location:497 → 546
      PSI; Plexin repeat

    2. NM_001169959.2 → NP_001163430.1  semaphorin 5c, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163430.1

      Status: REVIEWED

      Conserved Domains (3) summary
      cd11265
      Location:63 → 494
      Sema_5C; The Sema domain, a protein interacting module, of semaphorin 5C (sema5C)
      smart00209
      Location:672 → 723
      TSP1; Thrombospondin type 1 repeats
      pfam01437
      Location:495 → 544
      PSI; Plexin repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7YU67 Q7YU67
    Q9U631 Q9U631
    Q9VTT0 Q9VTT0
    Q9VTT0.3

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