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    Trs20 TRAPP subunit 20 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39769, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trs20provided by FlyBase
    Official Full Name
    TRAPP subunit 20provided by FlyBase
    Primary source
    FLYBASE:FBgn0266724
    Locus tag
    Dmel_CG5161
    See related
    AllianceGenome:FB:FBgn0266724
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE62842; CG5161; Dmel\CG5161; E(smoDN)B-left; Group B-left; l(3)72Dh; TRAPP2C; TRAPPC2; Trs20p
    Summary
    Involved in dsRNA transport and spermatogenesis. Part of TRAPPII protein complex and TRAPPIII protein complex. Human ortholog(s) of this gene implicated in X-linked spondyloepiphyseal dysplasia tarda. Orthologous to human TRAPPC2 (trafficking protein particle complex subunit 2) and TRAPPC2B (trafficking protein particle complex subunit 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Trs20 in Genome Data Viewer
    Location:
    72D9-72D9; 3-44 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16131001..16131632, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16124094..16124732, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Strumpellin Neighboring gene Phosphoglucose mutase 1 Neighboring gene Signal sequence receptor beta Neighboring gene enhanced level of genomic instability 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Parcas is the predominant Rab11-GEF for rhodopsin transport in Drosophila photoreceptors. Otsuka Y, et al. J Cell Sci, 2019 Aug 7. PMID 31296556
    2. Cryo-EM structure of metazoan TRAPPIII, the multi-subunit complex that activates the GTPase Rab1. Galindo A, et al. EMBO J, 2021 Jun 15. PMID 34018214, Free PMC Article
    3. TRAPPII is required for cleavage furrow ingression and localization of Rab11 in dividing male meiotic cells of Drosophila. Robinett CC, et al. J Cell Sci, 2009 Dec 15. PMID 19934220, Free PMC Article
    4. A genetic screen in Drosophila for identifying novel components of the hedgehog signaling pathway. Collins RT, et al. Genetics, 2005 May. PMID 15744048, Free PMC Article
    5. Identification of two pathways mediating protein targeting from ER to lipid droplets. Song J, et al. Nat Cell Biol, 2022 Sep. PMID 36050470, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi vesicle transport IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TRAPP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TRAPP complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of TRAPPII protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of TRAPPIII protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TRAPP subunit 20
    Names
    CG5161-PA
    TRAPP subunit 20 ortholog
    Trs20-PA
    enhancer of smoDN group B-left
    lethal (3) 72Dh

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16131001..16131632 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140584.3 → NP_648841.1  TRAPP subunit 20 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648841.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SYG9, Q9VUZ1
      UniProtKB/TrEMBL
      A0A1B2AK04
      Related
      FBpp0075246
      Conserved Domains (1) summary
      cd14825
      Location:3 → 137
      TRAPPC2_sedlin; Trafficking protein particle complex subunit 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VUZ1.2 Q9VUZ1

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