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    Syx8 Syntaxin 8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39847, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Syx8provided by FlyBase
    Official Full Name
    Syntaxin 8provided by FlyBase
    Primary source
    FLYBASE:FBgn0036643
    Locus tag
    Dmel_CG4109
    See related
    AllianceGenome:FB:FBgn0036643
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4109; Dm Syx8; Dmel\CG4109; DmSyx8; Syx; syx8; SYX8
    Summary
    Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in intracellular protein transport; synaptic vesicle docking; and vesicle fusion. Predicted to be located in plasma membrane. Predicted to be part of SNARE complex. Predicted to be active in endomembrane system. Is expressed in adult head. Orthologous to human STX8 (syntaxin 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Syx8 in Genome Data Viewer
    Location:
    73A10-73A10; 3-44 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16586108..16587057, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16579208..16580157, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Regulatory particle non-ATPase 12 Neighboring gene Ubiquinol-cytochrome c reductase core protein 2 Neighboring gene antisense RNA:CR45895 Neighboring gene uncharacterized protein Neighboring gene lethal (3) 73Ah Neighboring gene transformer

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An ELISA-based method for rapid genetic screens in Drosophila. Jay TR, et al. Proc Natl Acad Sci U S A, 2021 Oct 26. PMID 34686600, Free PMC Article
    2. Neural lineages of the Drosophila brain: a three-dimensional digital atlas of the pattern of lineage location and projection at the late larval stage. Pereanu W, et al. J Neurosci, 2006 May 17. PMID 16707805, Free PMC Article
    3. Role of DE-cadherin in neuroblast proliferation, neural morphogenesis, and axon tract formation in Drosophila larval brain development. Dumstrei K, et al. J Neurosci, 2003 Apr 15. PMID 12716940, Free PMC Article
    4. Morphogenesis and proliferation of the larval brain glia in Drosophila. Pereanu W, et al. Dev Biol, 2005 Jul 1. PMID 15907832
    5. Bruchpilot, a protein with homology to ELKS/CAST, is required for structural integrity and function of synaptic active zones in Drosophila. Wagh DA, et al. Neuron, 2006 Mar 16. PMID 16543132

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle docking ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SNARE complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    syntaxin 8
    Names
    CG4109-PA
    Syx8-PA
    dSyntaxin8
    syntaxin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16586108..16587057 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079389.4 → NP_524113.1  syntaxin 8 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524113.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NP24, Q9VV76
      Related
      FBpp0075124
      Conserved Domains (1) summary
      cd15852
      Location:147 → 205
      SNARE_Syntaxin8; SNARE motif of syntaxin 8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VV76 Q9VV76

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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