U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pfdn6 Prefoldin 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40176, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Pfdn6provided by FlyBase
    Official Full Name
    Prefoldin 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0036918
    Locus tag
    Dmel_CG7770
    See related
    AllianceGenome:FB:FBgn0036918
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH28557; CG7770; Dmel\CG7770; pfdn6
    Summary
    Predicted to enable protein-folding chaperone binding activity. Predicted to be involved in chaperone-mediated protein complex assembly and protein folding. Predicted to be part of prefoldin complex. Predicted to be active in cytoplasm. Is expressed in adult head. Orthologous to human PFDN6 (prefoldin subunit 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Pfdn6 in Genome Data Viewer
    Location:
    76D4-76D5; 3-46 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19923671..19924688)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19916771..19917788)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Regulatory particle non-ATPase 1 Neighboring gene Su(z)12 Neighboring gene Grasp65 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Prefoldin and Pins synergistically regulate asymmetric division and suppress dedifferentiation. Zhang Y, et al. Sci Rep, 2016 Mar 30. PMID 27025979, Free PMC Article
    2. Misato Controls Mitotic Microtubule Generation by Stabilizing the TCP-1 Tubulin Chaperone Complex [corrected]. Palumbo V, et al. Curr Biol, 2015 Jun 29. PMID 26096973, Free PMC Article
    3. Ciliary dynein motor preassembly is regulated by Wdr92 in association with HSP90 co-chaperone, R2TP. Zur Lage P, et al. J Cell Biol, 2018 Jul 2. PMID 29743191, Free PMC Article
    4. A Drosophila in vivo screen identifies store-operated calcium entry as a key regulator of adiposity. Baumbach J, et al. Cell Metab, 2014 Feb 4. PMID 24506874
    5. RNAi-Mediated Reverse Genetic Screen Identified Drosophila Chaperones Regulating Eye and Neuromuscular Junction Morphology. Raut S, et al. G3 (Bethesda), 2017 Jul 5. PMID 28500055, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of prefoldin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of prefoldin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    prefoldin 6
    Names
    CG7770-PA
    CG7770-PB
    Pfdn6-PA
    Pfdn6-PB

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19923671..19924688
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275150.1 → NP_001262079.1  prefoldin 6, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262079.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VW56
      UniProtKB/TrEMBL
      M9PD09
      Conserved Domains (1) summary
      cd00632
      Location:12 → 116
      Prefoldin_beta; Prefoldin beta; Prefoldin is a hexameric molecular chaperone complex, composed of two evolutionarily related subunits (alpha and beta), which are found in both eukaryotes and archaea. Prefoldin binds and stabilizes newly synthesized polypeptides ...

    2. NM_140902.2 → NP_649159.1  prefoldin 6, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649159.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VW56
      UniProtKB/TrEMBL
      M9PD09
      Related
      FBpp0074663
      Conserved Domains (1) summary
      cd00632
      Location:12 → 116
      Prefoldin_beta; Prefoldin beta; Prefoldin is a hexameric molecular chaperone complex, composed of two evolutionarily related subunits (alpha and beta), which are found in both eukaryotes and archaea. Prefoldin binds and stabilizes newly synthesized polypeptides ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PD09 M9PD09
    Q9VW56.1 Q9VW56

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools