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    CRIF CR6-interacting factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40395, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CRIFprovided by FlyBase
    Official Full Name
    CR6-interacting factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037102
    Locus tag
    Dmel_CG7172
    See related
    AllianceGenome:FB:FBgn0037102
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.316; CG7172; dCRIF; Dmel\CG7172
    Summary
    Involved in RNAi-mediated antiviral immune response and siRNA processing. Located in perinuclear region of cytoplasm. Is expressed in adult head. Orthologous to human GADD45GIP1 (GADD45G interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CRIF in Genome Data Viewer
    Location:
    78D6-78D6; 3-47 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21568059..21568898, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21561159..21561998, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Capability receptor Neighboring gene uncharacterized protein Neighboring gene Structural maintenance of chromosomes 5 Neighboring gene mir-193 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Requirement for CRIF1 in RNA interference and Dicer-2 stability. Lim SJ, et al. RNA Biol, 2014. PMID 25483042, Free PMC Article
    2. A map of directional genetic interactions in a metazoan cell. Fischer B, et al. Elife, 2015 Mar 6. PMID 25748138, Free PMC Article
    3. The mitochondrial outer membrane protein MDI promotes local protein synthesis and mtDNA replication. Zhang Y, et al. EMBO J, 2016 May 17. PMID 27053724, Free PMC Article
    4. Transcriptome analysis of FOXO-dependent hypoxia gene expression identifies Hipk as a regulator of low oxygen tolerance in Drosophila. Ding K, et al. G3 (Bethesda), 2022 Dec 1. PMID 36200850, Free PMC Article
    5. Identification of novel genes associated with longevity in Drosophila melanogaster - a computational approach. Hall BS, et al. Aging (Albany NY), 2019 Dec 3. PMID 31794428, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in RNAi-mediated antiviral immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in siRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CR6-interacting factor
    Names
    CG7172-PA
    CRIF-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21568059..21568898 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141076.5 → NP_649333.1  CR6-interacting factor [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649333.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VP13
      Related
      FBpp0078032
      Conserved Domains (1) summary
      pfam10147
      Location:29 → 231
      CR6_interact; Growth arrest and DNA-damage-inducible proteins-interacting protein 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VP13 Q9VP13

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