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    CG11426 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40471, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG11426provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037166
    Locus tag
    Dmel_CG11426
    See related
    AllianceGenome:FB:FBgn0037166
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Css1beta; Dmel\CG11426; LPP; LPP-like; PAP2; WUN-like
    Summary
    Predicted to enable phosphatidate phosphatase activity. Involved in phototransduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including CNS glial cell; embryonic head sensory system; embryonic optic lobe primordium; larval labral sensory complex; and sensory nervous system primordium. Orthologous to human PLPP1 (phospholipid phosphatase 1); PLPP2 (phospholipid phosphatase 2); and PLPP3 (phospholipid phosphatase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG11426 in Genome Data Viewer
    Location:
    79E4-79E4; 3-47 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22470556..22473509)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22463656..22466609)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45382 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CG11426 gene product negatively regulates glial population size in the Drosophila eye imaginal disc. Rhee JE, et al. Dev Neurobiol, 2021 Sep. PMID 34047015
    2. Decoupled differentiation of gene expression and coding sequence among Drosophila populations. Kohn MH, et al. Genes Genet Syst, 2008 Jun. PMID 18670138
    3. lazaro encodes a lipid phosphate phosphohydrolase that regulates phosphatidylinositol turnover during Drosophila phototransduction. Garcia-Murillas I, et al. Neuron, 2006 Feb 16. PMID 16476663
    4. Rhabdomere biogenesis in Drosophila photoreceptors is acutely sensitive to phosphatidic acid levels. Raghu P, et al. J Cell Biol, 2009 Apr 6. PMID 19349583, Free PMC Article
    5. Identification of a family of animal sphingomyelin synthases. Huitema K, et al. EMBO J, 2004 Jan 14. PMID 14685263, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in phospholipid dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phototransduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG11426-PA
    lipid phosphate phosphohydrolase
    NP_649394.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      22470556..22473509
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141137.3 → NP_649394.1  uncharacterized protein Dmel_CG11426 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649394.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5T219, Q7YU44, Q9VNT9
      Related
      FBpp0078158
      Conserved Domains (1) summary
      cd03384
      Location:130 → 285
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7YU44 Q7YU44
    Q9VNT9 Q9VNT9

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