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    Fadd Fas-associated death domain [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42594, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Faddprovided by FlyBase
    Official Full Name
    Fas-associated death domainprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038928
    Locus tag
    Dmel_CG12297
    See related
    AllianceGenome:FB:FBgn0038928
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG4; BG4_DROME; CG12297; dfadd; dFadd; dFADD; Dmel\CG12297; FAD; fadd; FADD
    Summary
    Enables CARD domain binding activity. Involved in several processes, including defense response to bacterium; positive regulation of defense response to virus by host; and sperm individualization. Located in cytoplasm. Is expressed in adult Malpighian tubule. Human ortholog(s) of this gene implicated in leukemia and primary immunodeficiency disease. Orthologous to human FADD (Fas associated via death domain). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Fadd in Genome Data Viewer
    Location:
    94A1-94A1; 3-74 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22034455..22035617)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17860177..17861339)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene small Cajal body-specific RNA : MeU5-G38 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pitchoune Neighboring gene held out wings

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila tumor necrosis factor Eiger promotes Myc supercompetition independent of canonical Jun N-terminal kinase signaling. Kodra AL, et al. Genetics, 2024 Sep 4. PMID 38985651, Free PMC Article
    2. Splice-activated UAS hairpin vector gives complete RNAi knockout of single or double target transcripts in Drosophila melanogaster. Reichhart JM, et al. Genesis, 2002 Sep-Oct. PMID 12324974
    3. Independent Proteolytic Activities Control the Stability and Size of Drosophila Inhibitor of Apoptosis 2 Protein. Guntermann S, et al. J Innate Immun, 2015. PMID 25968339, Free PMC Article
    4. Constitutive Immune Activity Promotes Tumorigenesis in Drosophila Intestinal Progenitor Cells. Petkau K, et al. Cell Rep, 2017 Aug 22. PMID 28834743
    5. dFADD, a novel death domain-containing adapter protein for the Drosophila caspase DREDD. Hu S, et al. J Biol Chem, 2000 Oct 6. PMID 10934188

    See all (151) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables CARD domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables caspase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables death receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium HMP PubMed 
    involved_in defense response to Gram-negative bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in extrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidoglycan recognition protein signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of antibacterial peptide biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of defense response to virus by host IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of innate immune response HMP PubMed 
    involved_in positive regulation of innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CD95 death-inducing signaling complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Fas-associated death domain
    Names
    BG4
    CG12297-PA
    Fadd-PA
    Fas-associated death domain ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22034455..22035617
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142749.3 → NP_651006.1  Fas-associated death domain [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651006.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V9R5, A4V9R6, A4V9R7, Q9V3B4
      UniProtKB/TrEMBL
      B9EQZ9, H0RN71
      Related
      FBpp0083574
      Conserved Domains (2) summary
      cd01670
      Location:154 → 234
      Death; Death Domain: a protein-protein interaction domain
      cl14633
      Location:22 → 71
      DD; Death Domain Superfamily of protein-protein interaction domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3B4.1 Q9V3B4

    Gene LinkOut

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