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    Saysd1 SAYSVFN motif domain containing 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43029, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Saysd1provided by FlyBase
    Official Full Name
    SAYSVFN motif domain containing 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0039291
    Locus tag
    Dmel_CG13663
    See related
    AllianceGenome:FB:FBgn0039291
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13663; Dmel\CG13663; SAYSD1
    Summary
    Involved in protein quality control for misfolded or incompletely synthesized proteins. Is expressed in adult head. Orthologous to human SAYSD1 (SAYSVFN motif domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Saysd1 in Genome Data Viewer
    Location:
    96C5-96C5; 3-87 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25214325..25215188, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21040047..21040910, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Cadherin 96Ca Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SAYSD1 senses UFMylated ribosome to safeguard co-translational protein translocation at the endoplasmic reticulum. Wang L, et al. Cell Rep, 2023 Jan 31. PMID 36848233, Free PMC Article
    2. Identification of GOLPH3 Partners in Drosophila Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders. Sechi S, et al. Cells, 2021 Sep 6. PMID 34571985, Free PMC Article
    3. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599810, Free PMC Article
    4. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article
    5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in protein quality control for misfolded or incompletely synthesized proteins IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SAYSVFN motif domain containing 1
    Names
    CG13663-PA
    Saysd1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25214325..25215188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143094.3 → NP_651351.1  SAYSVFN motif domain containing 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651351.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4QQ08, Q9VBW0
      Related
      FBpp0084247
      Conserved Domains (1) summary
      pfam10260
      Location:100 → 164
      SAYSvFN; Uncharacterized conserved domain (SAYSvFN)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VBW0 Q9VBW0

    Gene LinkOut

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