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    CG31089 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43135, updated on 17-Dec-2024

    Summary

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    Official Symbol
    CG31089provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051089
    Locus tag
    Dmel_CG31089
    See related
    AllianceGenome:FB:FBgn0051089
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5990; Dmel\CG31089
    Summary
    Predicted to enable triacylglycerol lipase activity. Predicted to be involved in lipid metabolic process. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG31089 in Genome Data Viewer
    Location:
    96F7-96F7; 3-89 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25902643..25904178)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21728365..21729900)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43259 Neighboring gene Multicopper oxidase 3 Neighboring gene uncharacterized protein Neighboring gene kin of rumpel Neighboring gene uncharacterized protein Neighboring gene Crustacean cardioactive peptide receptor Neighboring gene long non-coding RNA:CR34024

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila HNF4 acts in distinct tissues to direct a switch between lipid storage and export in the gut. Vonolfen MC, et al. Cell Rep, 2024 Sep 24. PMID 39235946
    2. Altered lipid homeostasis in Drosophila InsP3 receptor mutants leads to obesity and hyperphagia. Subramanian M, et al. Dis Model Mech, 2013 May. PMID 23471909, Free PMC Article
    3. ATF4 Responds to Metabolic Stress in Drosophila. Ok S, et al. Front Biosci (Landmark Ed), 2023 Dec 26. PMID 38179767
    4. Control of lipid metabolism by tachykinin in Drosophila. Song W, et al. Cell Rep, 2014 Oct 9. PMID 25263556, Free PMC Article
    5. Spatiotemporal dynamics and genome-wide association genome-wide association analysis of desiccation tolerance in Drosophila melanogaster. Rajpurohit S, et al. Mol Ecol, 2018 Sep. PMID 30051644, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables triacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG31089-PA
    NP_733128.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25902643..25904178
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170249.2 → NP_733128.1  uncharacterized protein Dmel_CG31089 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733128.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VBK6
      Related
      FBpp0084316
      Conserved Domains (2) summary
      pfam04083
      Location:48 → 110
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      cl21494
      Location:86 → 237
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VBK6 Q9VBK6

    Gene LinkOut

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