Cisd2 CDGSH iron sulfur domain 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cisd2provided by FlyBase
Official Full Name: CDGSH iron sulfur domain 2provided by FlyBase
Primary source: FLYBASE:FBgn0062442
Locus tag: Dmel_CG1458
See related: AllianceGenome:FB:FBgn0062442
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:RE49709; CG1458; cisd2; Dmel\CG1458; Dosmit; Dsm; dWFS2; mitoNEET; MitoNEET
Summary: Predicted to enable 2 iron, 2 sulfur cluster binding activity and L-cysteine transaminase activity. Involved in intracellular iron ion homeostasis and mitochondrial transport. Is active in mitochondrial outer membrane. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in Wolfram syndrome 2. Orthologous to several human genes including CISD2 (CDGSH iron sulfur domain 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (29222217..29223428, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (25047939..25049150, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Vesicular transport mediates the uptake of cytoplasmic proteins into mitochondria in Drosophila melanogaster.
Title: Vesicular transport mediates the uptake of cytoplasmic proteins into mitochondria in Drosophila melanogaster.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IBA Inferred from Biological aspect of Ancestor more info
enables 2 iron, 2 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables 2 iron, 2 sulfur cluster binding	ISS Inferred from Sequence or Structural Similarity more info
enables L-cysteine transaminase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in intracellular iron ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular iron ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of autophagy	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain