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    ND-49 NADH dehydrogenase (ubiquinone) 49 kDa subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43798, updated on 17-Dec-2024

    Summary

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    Official Symbol
    ND-49provided by FlyBase
    Official Full Name
    NADH dehydrogenase (ubiquinone) 49 kDa subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039909
    Locus tag
    Dmel_CG1970
    See related
    AllianceGenome:FB:FBgn0039909
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG 1970; CG1970; Dmel\CG1970; dNDUFS2; dNDUFS2A; Ndufs2; NDUFS2; NUCM
    Summary
    Predicted to enable NAD binding activity; oxidoreductase activity, acting on NAD(P)H; and quinone binding activity. Predicted to contribute to NADH dehydrogenase activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Located in mitochondrion. Part of respiratory chain complex I. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in Leigh disease; hypertrophic cardiomyopathy; inherited metabolic disorder; multiple sclerosis; and nuclear type mitochondrial complex I deficiency 6. Orthologous to human NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ND-49 in Genome Data Viewer
    Location:
    102C5-102C5; 4-0 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (568296..571554, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (588922..592180, complement)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene Thymine DNA glycosylase Neighboring gene long non-coding RNA:CR43958 Neighboring gene Purine-rich binding protein-alpha Neighboring gene ephrin Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CGG repeat expansion in NOTCH2NLC causes mitochondrial dysfunction and progressive neurodegeneration in Drosophila model. Yu J, et al. Proc Natl Acad Sci U S A, 2022 Oct 11. PMID 36191230, Free PMC Article
    2. Methylene blue rescues heart defects in a Drosophila model of Friedreich's ataxia. Tricoire H, et al. Hum Mol Genet, 2014 Feb 15. PMID 24105471
    3. Comparison of dot chromosome sequences from D. melanogaster and D. virilis reveals an enrichment of DNA transposon sequences in heterochromatic domains. Slawson EE, et al. Genome Biol, 2006. PMID 16507169, Free PMC Article
    4. Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells. Ojha R, et al. Dev Cell, 2022 Jan 24. PMID 35077680, Free PMC Article
    5. HP1a recruitment to promoters is independent of H3K9 methylation in Drosophila melanogaster. Figueiredo ML, et al. PLoS Genet, 2012. PMID 23166515, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c569643-569608 mobile_element_type = transposon:1360{}2006

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADH dehydrogenase (ubiquinone) activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    contributes_to NADH dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables quinone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, NADH to ubiquinone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, NADH to ubiquinone IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitochondrial electron transport, NADH to ubiquinone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase (ubiquinone) 49 kDa subunit
    Names
    CG1970-PA
    CG1970-PB
    FBpp0088174
    NADH ubiquinone oxidoreductase 49 kDa
    NADH-ubiquinone oxidoreductase 49 kDa subunit
    NADH:ubiquinone oxidoreductase 49 kDa subunit
    ND-49-PA
    ND-49-PB
    NP_001259064.1
    NP_651926.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      568296..571554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272135.1 → NP_001259064.1  NADH dehydrogenase (ubiquinone) 49 kDa subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259064.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V4E0
      Conserved Domains (2) summary
      PRK06075
      Location:79 → 468
      PRK06075; NADH dehydrogenase subunit D; Validated
      COG0649
      Location:79 → 468
      NuoD; NADH:ubiquinone oxidoreductase 49 kD subunit (chain D) [Energy production and conversion]

    2. NM_143669.2 → NP_651926.1  NADH dehydrogenase (ubiquinone) 49 kDa subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651926.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V4E0
      Related
      FBpp0088174
      Conserved Domains (2) summary
      PRK06075
      Location:79 → 468
      PRK06075; NADH dehydrogenase subunit D; Validated
      COG0649
      Location:79 → 468
      NuoD; NADH:ubiquinone oxidoreductase 49 kD subunit (chain D) [Energy production and conversion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V4E0 Q9V4E0

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