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    CG4467 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42747, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4467provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039064
    Locus tag
    Dmel_CG4467
    See related
    AllianceGenome:FB:FBgn0039064
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13825; Dmel\CG4467
    Summary
    Predicted to be active in cytoplasm; extracellular space; and membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in cervix carcinoma and type 2 diabetes mellitus. Orthologous to human ERAP1 (endoplasmic reticulum aminopeptidase 1); ERAP2 (endoplasmic reticulum aminopeptidase 2); and LNPEP (leucyl and cystinyl aminopeptidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4467 in Genome Data Viewer
    Location:
    94E7-94E8; 3-78 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23227727..23248903, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19053449..19074625, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Inwardly rectifying potassium channel 1 Neighboring gene uncharacterized protein Neighboring gene cap-n-collar Neighboring gene fuzzy onions Neighboring gene Rad60 Neighboring gene Elongin A Neighboring gene will decrease acetylation

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aging Fly Cell Atlas identifies exhaustive aging features at cellular resolution. Lu TC, et al. Science, 2023 Jun 16. PMID 37319212, Free PMC Article
    2. Genetic analysis of dPsa, the Drosophila orthologue of puromycin-sensitive aminopeptidase, suggests redundancy of aminopeptidases. Schulz C, et al. Dev Genes Evol, 2001 Dec. PMID 11819115
    3. Genome-wide identification and comparative analysis of Cry toxin receptor families in 7 insect species with a focus on Spodoptera litura. Li Q, et al. Insect Sci, 2022 Jun. PMID 34405540
    4. Identification of circadian-clock-regulated enhancers and genes of Drosophila melanogaster by transposon mobilization and luciferase reporting of cyclical gene expression. Stempfl T, et al. Genetics, 2002 Feb. PMID 11861563, Free PMC Article
    5. Minos as a genetic and genomic tool in Drosophila melanogaster. Metaxakis A, et al. Genetics, 2005 Oct. PMID 15972463, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables metalloaminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    NOT enables peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in peptide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4467-PA
    CG4467-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23227727..23248903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001043282.2 → NP_001036747.1  uncharacterized protein Dmel_CG4467, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036747.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KI25, Q6NNV4
      Conserved Domains (3) summary
      pfam01433
      Location:138 → 593
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:784 → 1078
      ERAP1_C; ERAP1-like C-terminal domain
      cl14813
      Location:145 → 682
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

    2. NM_142876.4 → NP_651133.2  uncharacterized protein Dmel_CG4467, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651133.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YU41, Q9VCP4
      Conserved Domains (3) summary
      pfam01433
      Location:101 → 556
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:747 → 1041
      ERAP1_C; ERAP1-like C-terminal domain
      cl14813
      Location:108 → 645
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0KI25 Q0KI25
    Q7YU41 Q7YU41
    Q9VCP4 Q9VCP4

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