U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    apolpp apolipophorin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43827, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    apolppprovided by FlyBase
    Official Full Name
    apolipophorinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0087002
    Locus tag
    Dmel_CG11064
    See related
    AllianceGenome:FB:FBgn0087002
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ApoL1; ApoL2; apoLI; ApoLI; apoLII; ApoLII; apoLpp; apoLPP; Apolpp; ApoLpp; CG11064; chr4:1088013..1088173; Dmel\CG11064; DRBP; lipophorin; Lipophorin; Lpp; LPP; rfabg; Rfabg; RFABG; Rfabp; RfaBp; RfaBP; RFABP; RFBP; T3
    Summary
    Enables several functions, including heme binding activity; microtubule binding activity; and retinol binding activity. Involved in lipid transport involved in lipid storage; lipoprotein transport; and positive regulation of signal transduction. Located in basal part of cell; endocytic vesicle; and extracellular space. Is expressed in several structures, including adult head; adult heart; adult posterior midgut; fat body; and hemolymph. Used to study congenital heart disease. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See apolpp in Genome Data Viewer
    Location:
    102F7-102F8; 4-0 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (1060969..1077273)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (1081595..1097899)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene ATP synthase, beta subunit Neighboring gene uncharacterized protein Neighboring gene Calcium/calmodulin-dependent protein kinase II Neighboring gene Zyxin Neighboring gene Activin-beta Neighboring gene shaven Neighboring gene Calsyntenin

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular characterization and developmental expression of a retinoid- and fatty acid-binding glycoprotein from Drosophila. A putative lipophorin. Kutty RK, et al. J Biol Chem, 1996 Aug 23. PMID 8702812
    2. Purification of adult Drosophila melanogaster lipophorin and its role in hydrocarbon transport. Pho DB, et al. Arch Insect Biochem Physiol, 1996. PMID 8742826
    3. The structure of vitellogenin provides a molecular model for the assembly and secretion of atherogenic lipoproteins. Mann CJ, et al. J Mol Biol, 1999 Jan 8. PMID 9878414
    4. Heme-binding by Drosophila retinoid- and fatty acid-binding glycoprotein (RFABG), a member of the proapolipophorin gene family. Duncan T, et al. J Lipid Res, 1999 Jul. PMID 10393207
    5. Insect endosymbiont proliferation is limited by lipid availability. Herren JK, et al. Elife, 2014 Jul 15. PMID 25027439, Free PMC Article

    See all (176) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Early life exercise training and inhibition of apoLpp mRNA expression to improve age-related arrhythmias and prolong the average lifespan in Drosophila melanogaster.
      Title: Early life exercise training and inhibition of apoLpp mRNA expression to improve age-related arrhythmias and prolong the average lifespan in Drosophila melanogaster.
    2. Wingless, Hedgehog and glycophosphatidylinositol-linked proteins copurify with lipophorin, and co-localize with it in the developing wing epithelium of Drosophila.
      Title: Lipoprotein particles are required for Hedgehog and Wingless signalling.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    mobile_element

    • Loc: 1061502-1061989 mobile_element_type = transposon:INE-1{}3410

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables fatty acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lipid transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables retinol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid transport involved in lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipoprotein transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basal part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    apolipophorin
    Names
    CG11064-PA
    CG11064-PB
    CG11064-PC
    CG11064-PD
    Retinoid- and fatty acid-binding glycoprotein
    Retinoid- and fatty acid-binding protein
    Retinoid- and fatty-acid binding protein
    Retinoid-fatty acid-binding glycoprotein
    RfaBp
    apolipophorin I
    apolipophorin II
    apolipophorin-2
    apolpp-PA
    apolpp-PB
    apolpp-PC
    apolpp-PD
    lipophorin
    retinoid and fatty acid binding glycoprotein
    retinoid and fatty acid binding protein
    retinoid and fatty-acid binding protein
    retinoid- and fatty acid-binding gene
    retinoid-fatty acid binding protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      1060969..1077273
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297791.1 → NP_001284720.1  apolipophorin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284720.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8ST55, Q8T6S6, Q94907, Q9V496
      UniProtKB/TrEMBL
      L0MPS3
      Conserved Domains (4) summary
      smart00216
      Location:2789 → 2931
      VWD; von Willebrand factor (vWF) type D domain
      pfam01347
      Location:43 → 573
      Vitellogenin_N; Lipoprotein amino terminal region
      pfam06448
      Location:932 → 1031
      DUF1081; Domain of Unknown Function (DUF1081)
      pfam09172
      Location:605 → 911
      DUF1943; Domain of unknown function (DUF1943)

    2. NM_001297792.1 → NP_001284721.1  apolipophorin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284721.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8ST55, Q8T6S6, Q94907, Q9V496
      UniProtKB/TrEMBL
      L0MPS3
      Conserved Domains (4) summary
      smart00216
      Location:2789 → 2931
      VWD; von Willebrand factor (vWF) type D domain
      pfam01347
      Location:43 → 573
      Vitellogenin_N; Lipoprotein amino terminal region
      pfam06448
      Location:932 → 1031
      DUF1081; Domain of Unknown Function (DUF1081)
      pfam09172
      Location:605 → 911
      DUF1943; Domain of unknown function (DUF1943)

    3. NM_001272156.1 → NP_001259085.1  apolipophorin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259085.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8ST55, Q8T6S6, Q94907, Q9V496
      UniProtKB/TrEMBL
      L0MPS3
      Conserved Domains (4) summary
      smart00216
      Location:2789 → 2931
      VWD; von Willebrand factor (vWF) type D domain
      pfam01347
      Location:43 → 573
      Vitellogenin_N; Lipoprotein amino terminal region
      pfam06448
      Location:932 → 1031
      DUF1081; Domain of Unknown Function (DUF1081)
      pfam09172
      Location:605 → 911
      DUF1943; Domain of unknown function (DUF1943)

    4. NM_079895.3 → NP_524634.2  apolipophorin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524634.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8ST55, Q8T6S6, Q94907, Q9V496
      UniProtKB/TrEMBL
      L0MPS3
      Related
      FBpp0088252
      Conserved Domains (4) summary
      smart00216
      Location:2789 → 2931
      VWD; von Willebrand factor (vWF) type D domain
      pfam01347
      Location:43 → 573
      Vitellogenin_N; Lipoprotein amino terminal region
      pfam06448
      Location:932 → 1031
      DUF1081; Domain of Unknown Function (DUF1081)
      pfam09172
      Location:605 → 911
      DUF1943; Domain of unknown function (DUF1943)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    L0MPS3 L0MPS3
    Q9V496.2 Q9V496

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools