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    lost lost [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40559, updated on 17-Dec-2024

    Summary

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    Official Symbol
    lostprovided by FlyBase
    Official Full Name
    lostprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263594
    Locus tag
    Dmel_CG14648
    See related
    AllianceGenome:FB:FBgn0263594
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.126; CG14648; Dmel\CG14648; growl; Growl; Lost; nev; nvd
    Summary
    Involved in pole cell development and pole plasm oskar mRNA localization. Located in cytoplasm. Part of ribonucleoprotein complex. Is expressed in several structures, including adult brain cell body rind; adult head; adult heart; germline cell; and ovary. Orthologous to human MTHFSD (methenyltetrahydrofolate synthetase domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See lost in Genome Data Viewer
    Location:
    82A6-82A6; 3-47.1 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4403076..4407182)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (228798..232904)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45187 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene spargel Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ouija board: A transcription factor evolved for only one target in steroid hormone biosynthesis in the fruit fly Drosophila melanogaster. Niwa YS, et al. Transcription, 2016 Oct 19. PMID 27434771, Free PMC Article
    2. hkb is required for DIP-α expression and target recognition in the Drosophila neuromuscular circuit. Wang Y, et al. Commun Biol, 2024 Apr 27. PMID 38678127, Free PMC Article
    3. Molecular insights into RNA recognition and gene regulation by the TRIM-NHL protein Mei-P26. Salerno-Kochan A, et al. Life Sci Alliance, 2022 Aug. PMID 35512835, Free PMC Article
    4. A late phase of germ plasm accumulation during Drosophila oogenesis requires lost and rumpelstiltskin. Sinsimer KS, et al. Development, 2011 Aug. PMID 21752933, Free PMC Article
    5. Drosophila patterning is established by differential association of mRNAs with P bodies. Weil TT, et al. Nat Cell Biol, 2012 Dec. PMID 23178881, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in anterior/posterior pattern specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in anterior/posterior pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in pole cell development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in pole plasm mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pole plasm oskar mRNA localization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    part_of precatalytic spliceosome HDA PubMed 
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lost
    Names
    CG14648-PA
    growl
    lost boys
    lost-PA
    neverland

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      4403076..4407182
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141209.3 → NP_649466.1  lost [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649466.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGE9, Q9VN21
      Related
      FBpp0078561
      Conserved Domains (2) summary
      cd12270
      Location:384 → 455
      RRM_MTHFSD; RNA recognition motif in vertebrate methenyltetrahydrofolate synthetase domain-containing proteins
      cl00360
      Location:67 → 238
      5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IGE9 Q8IGE9
    Q9VN21 Q9VN21

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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