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    ktub king tubby [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37400, updated on 27-Dec-2024

    Summary

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    Official Symbol
    ktubprovided by FlyBase
    Official Full Name
    king tubbyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015721
    Locus tag
    Dmel_CG9398
    See related
    AllianceGenome:FB:FBgn0015721
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    87D3S; CG9398; D-tulp; Dmel\CG9398; dTulp; dTULP; Dtulp; ESTS:87D3S; king-tubby; King-tubby; King-Tubby; tulp; Tulp; TULP
    Summary
    Involved in several processes, including negative regulation of opsin-mediated signaling pathway; response to sucrose; and triglyceride homeostasis. Located in several cellular components, including cilium; neuronal cell body; and rhabdomere. Is expressed in several structures, including endoderm anlage; head epidermis primordium; sense organ; sensory nervous system primordium; and sensory neurons. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 15; retinitis pigmentosa; and retinitis pigmentosa 14. Orthologous to several human genes including TULP1 (TUB like protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See ktub in Genome Data Viewer
    Location:
    57B20-57C2; 2-93 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21101928..21123704)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16989433..17011209)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Trehalase Neighboring gene Rabaptin-5 Neighboring gene uncharacterized protein Neighboring gene Gar1 ribonucleoprotein Neighboring gene uncharacterized protein Neighboring gene Transmembrane O-mannosyltransferase targeting cadherins 3 Neighboring gene mago nashi Neighboring gene magi

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and expression patterns of Drosophila TULP and TUSP, members of the tubby-like gene family. Ronshaugen M, et al. Mech Dev, 2002 Sep. PMID 12204260
    2. Drosophila king tubby (ktub) mediates light-induced rhodopsin endocytosis and retinal degeneration. Chen SF, et al. J Biomed Sci, 2012 Dec 10. PMID 23228091, Free PMC Article
    3. Role of fat body lipogenesis in protection against the effects of caloric overload in Drosophila. Musselman LP, et al. J Biol Chem, 2013 Mar 22. PMID 23355467, Free PMC Article
    4. Sub-Ciliary Segregation of Two Drosophila Transient Receptor Potential Channels Begins at the Initial Stage of Their Pre-Ciliary Trafficking. Kwon Y, et al. Mol Cells, 2020 Dec 31. PMID 33323559, Free PMC Article
    5. dTULP, the Drosophila melanogaster homolog of tubby, regulates transient receptor potential channel localization in cilia. Park J, et al. PLoS Genet, 2013. PMID 24068974, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This is the first demonstration that dTULP regulates TRP channel localization in cilia, and suggests that dTULP is a protein that regulates ciliary neurosensory functions.
      Title: dTULP, the Drosophila melanogaster homolog of tubby, regulates transient receptor potential channel localization in cilia.
    2. The results in this study delimit the novel function of Ktub in Rh1 endocytosis and retinal degeneration
      Title: Drosophila king tubby (ktub) mediates light-induced rhodopsin endocytosis and retinal degeneration.
    3. TULP is principally expressed in the embryonic central and peripheral nervous systems.
      Title: Structure and expression patterns of Drosophila TULP and TUSP, members of the tubby-like gene family.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of opsin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to cilium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to sucrose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in triglyceride homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in rhabdomere IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    king tubby
    Names
    CG9398-PB
    CG9398-PC
    Tubby-like
    dTULP
    king-tubby
    ktub-PB
    ktub-PC
    tubby-like protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21101928..21123704
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137705.3 → NP_611549.2  king tubby, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611549.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86PC9
      Conserved Domains (1) summary
      pfam01167
      Location:228 → 462
      Tub; Tub family

    2. NM_206189.2 → NP_995911.1  king tubby, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995911.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86PC9, Q8MUB4, Q9W2L5
      Conserved Domains (1) summary
      pfam01167
      Location:219 → 453
      Tub; Tub family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86PC9.1 Q86PC9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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