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    Aldh7A1 Aldehyde dehydrogenase 7 family member A1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40097, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Aldh7A1provided by FlyBase
    Official Full Name
    Aldehyde dehydrogenase 7 family member A1provided by FlyBase
    Primary source
    FLYBASE:FBgn0036857
    Locus tag
    Dmel_CG9629
    See related
    AllianceGenome:FB:FBgn0036857
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ALDH7A1; CG9629; Dmel\CG9629
    Summary
    Predicted to enable aldehyde dehydrogenase (NAD+) activity. Predicted to be located in mitochondrion. Is expressed in adult head; adult heart; border follicle cell; embryonic/larval fat body; and yolk nucleus. Human ortholog(s) of this gene implicated in early-onset vitamin B6-dependent epilepsy 4. Orthologous to human ALDH7A1 (aldehyde dehydrogenase 7 family member A1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Aldh7A1 in Genome Data Viewer
    Location:
    76A3-76A3; 3-45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19266473..19268913, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19259573..19262013, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45210 Neighboring gene nessy Neighboring gene Blocked early in transport 1 Neighboring gene Max Neighboring gene uncharacterized protein Neighboring gene Methyltransferase like 5 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Metabolic control of PPAR activity by aldehyde dehydrogenase regulates invasive cell behavior and predicts survival in hepatocellular and renal clear cell carcinoma. Andrejeva D, et al. BMC Cancer, 2018 Nov 28. PMID 30486822, Free PMC Article
    2. Drosophila melanogaster as a versatile model organism to study genetic epilepsies: An overview. Fischer FP, et al. Front Mol Neurosci, 2023. PMID 36873106, Free PMC Article
    3. EAST Organizes Drosophila Insulator Proteins in the Interchromosomal Nuclear Compartment and Modulates CP190 Binding to Chromatin. Golovnin A, et al. PLoS One, 2015. PMID 26489095, Free PMC Article
    4. Systematic analysis of the transcriptional switch inducing migration of border cells. Borghese L, et al. Dev Cell, 2006 Apr. PMID 16580994, Free PMC Article
    5. Post-transcriptional repression of the Drosophila midkine and pleiotrophin homolog miple by HOW is essential for correct mesoderm spreading. Toledano-Katchalski H, et al. Development, 2007 Oct. PMID 17728343

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables aldehyde dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aldehyde dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    aldehyde dehydrogenase 7 family member A1
    Names
    Aldh7A1-PA
    CG9629-PA
    NP_649099.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19266473..19268913 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140842.3 → NP_649099.1  aldehyde dehydrogenase 7 family member A1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649099.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXQ1, Q9VVX8
      Related
      FBpp0074784
      Conserved Domains (1) summary
      cd07130
      Location:51 → 526
      ALDH_F7_AASADH; NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SXQ1 Q8SXQ1

    Gene LinkOut

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