Keap1 Keap1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Keap1provided by FlyBase
Official Full Name: Keap1provided by FlyBase
Primary source: FLYBASE:FBgn0038475
Locus tag: Dmel_CG3962
See related: AllianceGenome:FB:FBgn0038475
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3962; dkeap-1; dkeap1; dKeap1; dKEAP1; Dmel\CG3962; DmKeap1; keap; keap-1; Keap-1; keap1; KEAP1; nrf-2; Nrf-2
Summary: Enables ubiquitin-like ligase-substrate adaptor activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process; response to oxidative stress; and reticulophagy. Located in nucleus and polytene chromosome puff. Part of Cul3-RING ubiquitin ligase complex. Is expressed in several structures, including amnioserosa; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; and mesoderm. Human ortholog(s) of this gene implicated in gallbladder cancer. Orthologous to human KEAP1 (kelch like ECH associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 89E11-89E12; 3-59 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (17073942..17079945, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (12899664..12905667, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interaction with B-type lamin reveals the function of Drosophila Keap1 xenobiotic response factor in nuclear architecture.
Title: Interaction with B-type lamin reveals the function of Drosophila Keap1 xenobiotic response factor in nuclear architecture.
PINK1, Keap1, and Rtnl1 regulate selective clearance of endoplasmic reticulum during development.
Title: PINK1, Keap1, and Rtnl1 regulate selective clearance of endoplasmic reticulum during development.
Macrophage Nrf 2 the rescue.
Title: Macrophage Nrf 2 the rescue.
Drosophila Keap1 xenobiotic response factor regulates developmental transcription through binding to chromatin.
Title: Drosophila Keap1 xenobiotic response factor regulates developmental transcription through binding to chromatin.
Exploring the correlation between deltamethrin stress and Keap1-Nrf2-ARE pathway from Drosophila melanogaster RNASeq data.
Title: Exploring the correlation between deltamethrin stress and Keap1-Nrf2-ARE pathway from Drosophila melanogaster RNASeq data.
Together with the facts that Maf-S regulates ROS levels and genetically interacts with Keap1/Nrf2 in GSC maintenance, our study suggests that Maf-S plays an important role in the Drosophila testis GSC maintenance by participating in the regulation of redox homeost
Title: Small Maf functions in the maintenance of germline stem cells in the Drosophila testis.
Data suggest that blocking the specific interaction of Nrf2/cncC (cap-n-collar isoform C) with Keap1 may provide an exciting new avenue for the discovery of disease-modifying treatments for Alzheimer's disease (AD) and potentially other neurodegenerative conditions.
Title: Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease.
Consistent with the independent modes of CncC regulation by Keap1 and Fs(1)h, combinations of drugs that can specifically target these pathways cause a strong synergistic and specific activation of protective CncC- dependent gene expression and boosts oxidative stress resistance.
Title: Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein.
cooperatively activate developmental genes, in contrast to their conserved antagonizing effect to xenobiotic response transcription
Title: Multiple roles of Nrf2-Keap1 signaling: regulation of development and xenobiotic response using distinct mechanisms.
dKeap1 and CncC have a xenobiotic-specific gene activation response due to their combinatorial chromatin-binding specificities and transcriptional activities
Title: Visualization of the Drosophila dKeap1-CncC interaction on chromatin illumines cooperative, xenobiotic-specific gene activation.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like ligase-substrate adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reticulophagy	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul3-RING ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome puff	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Keap1

Names: CG3962-PA; CG3962-PB; CG3962-PC; Keap1-PA; Keap1-PB; Keap1-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

17073942..17079945 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_176508.3 → NP_788685.1 Keap1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788685.1

Status: REVIEWED

UniProtKB/TrEMBL

A9UNI1, Q9VEN5

Related

FBpp0082865

Conserved Domains (6) summary

smart00612
Location:446 → 491

Kelch; Kelch domain

PHA03098
Location:60 → 567

PHA03098; kelch-like protein; Provisional

sd00038
Location:435 → 478

Kelch; KELCH repeat [structural motif]

pfam00651
Location:48 → 151

BTB; BTB/POZ domain

pfam01344
Location:482 → 524

Kelch_1; Kelch motif

pfam07707
Location:160 → 262

BACK; BTB And C-terminal Kelch
NM_142337.3 → NP_650594.1 Keap1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_650594.1

Status: REVIEWED

UniProtKB/TrEMBL

A9UNI1, Q9VEN5

Related

FBpp0082863

Conserved Domains (6) summary

smart00612
Location:446 → 491

Kelch; Kelch domain

PHA03098
Location:60 → 567

PHA03098; kelch-like protein; Provisional

sd00038
Location:435 → 478

Kelch; KELCH repeat [structural motif]

pfam00651
Location:48 → 151

BTB; BTB/POZ domain

pfam01344
Location:482 → 524

Kelch_1; Kelch motif

pfam07707
Location:160 → 262

BACK; BTB And C-terminal Kelch
NM_169744.3 → NP_732202.2 Keap1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732202.2

Status: REVIEWED

UniProtKB/TrEMBL

A9UNI1, Q7KSF5

Related

FBpp0082864

Conserved Domains (6) summary

smart00612
Location:478 → 523

Kelch; Kelch domain

PHA03098
Location:92 → 599

PHA03098; kelch-like protein; Provisional

sd00038
Location:467 → 510

Kelch; KELCH repeat [structural motif]

pfam00651
Location:80 → 183

BTB; BTB/POZ domain

pfam01344
Location:514 → 556

Kelch_1; Kelch motif

pfam07707
Location:192 → 294

BACK; BTB And C-terminal Kelch