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    Cyp4d2 Cytochrome P450 4d2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31192, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp4d2provided by FlyBase
    Official Full Name
    Cytochrome P450 4d2provided by FlyBase
    Primary source
    FLYBASE:FBgn0011576
    Locus tag
    Dmel_CG3466
    See related
    AllianceGenome:FB:FBgn0011576
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4d2; CG3466; Cyp4D2; CYP4D2; Cyt-P450-4D2; Dmel\CG3466; EG:152A3.4; P-450; P450
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head; embryonic/larval midgut; and organism. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp4d2 in Genome Data Viewer
    Location:
    2E1-2E1; 1-0.8 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2176006..2178728)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2070039..2072761)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) B14.5 A subunit Neighboring gene antisense RNA:CR45479 Neighboring gene Cytochrome P450 4d14 Neighboring gene antisense RNA:CR44690 Neighboring gene Cytochrome P450 4ae1 Neighboring gene prune Neighboring gene Nonsense-mediated mRNA 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cluster of cytochrome P450 genes on the X chromosome of Drosophila melanogaster. Frolov MV, et al. DNA Cell Biol, 1994 Jun. PMID 8024706
    2. A new cytochrome P450 from Drosophila melanogaster, CYP4G15, expressed in the nervous system. Maïbèche-Coisne M, et al. Biochem Biophys Res Commun, 2000 Jul 14. PMID 10891384
    3. A field-based quantitative analysis of sublethal effects of air pollution on pollinators. Thimmegowda GG, et al. Proc Natl Acad Sci U S A, 2020 Aug 25. PMID 32778582, Free PMC Article
    4. The involvement of cytochrome P450 monooxygenases in methanol elimination in Drosophila melanogaster larvae. Wang SP, et al. Arch Insect Biochem Physiol, 2012 Apr. PMID 22508581
    5. Association of detoxification enzymes with butene-fipronil in larvae and adults of Drosophila melanogaster. Arain MS, et al. Environ Sci Pollut Res Int, 2018 Apr. PMID 29380196

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 4d2
    Names
    CG3466-PA
    CG3466-PB
    Cyp4d2-PA
    Cyp4d2-PB
    cytochrome P-450
    cytochrome P450
    cytochrome P450 4D2
    cytochrome P450-4d2
    NP_001284806.1
    NP_525043.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2176006..2178728
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297877.1 → NP_001284806.1  cytochrome P450 4d2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284806.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18651, O18674, O46053, Q27588, Q27589, Q9W514
      UniProtKB/TrEMBL
      X2JI29
      Conserved Domains (1) summary
      pfam00067
      Location:32 → 495
      p450; Cytochrome P450

    2. NM_080304.3 → NP_525043.1  cytochrome P450 4d2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525043.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18651, O18674, O46053, Q27588, Q27589, Q9W514
      UniProtKB/TrEMBL
      X2JI29
      Related
      FBpp0070371
      Conserved Domains (1) summary
      pfam00067
      Location:32 → 495
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q27589.2 Q27589
    X2JI29 X2JI29

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